Table 1 Patient characteristics at hospital admission
Global | Early IMV | Delayed IMV | p value | N | |
|---|---|---|---|---|---|
n = 205 Median [IQR] or n (%) | n = 140 Median [IQR] or n (%) | n = 65 Median [IQR] or n (%) | |||
Sociodemographic data | |||||
Sex, woman | 53 (25.9%) | 34 (24.3%) | 19 (29.2%) | 0.561 | 205 |
Age, years | 63.0 [56.0; 70.0] | 63.0 [54.0; 71.0] | 63.0 [59.0; 69.0] | 0.380 | 205 |
Smoking history | 0.061 | 183 | |||
Nonsmoker | 99 (54.1%) | 75 (59.5%) | 24 (42.1%) | ||
Current | 11 (6.01%) | 8 (6.35%) | 3 (5.26%) | ||
Former | 73 (39.9%) | 43 (34.1%) | 30 (52.6%) | ||
Comorbidities | |||||
Obesity | 108 (52.9%) | 78 (56.1%) | 30 (46.2%) | 0.239 | 204 |
Hypertension | 110 (53.7%) | 77 (55.0%) | 33 (50.8%) | 0.678 | 205 |
Diabetes mellitus | 65 (31.7%) | 52 (37.1%) | 13 (20.0%) | 0.022 | 205 |
Chronic heart disease | 26 (12.7%) | 22 (15.7%) | 4 (6.15%) | 0.091 | 205 |
Chronic renal disease | 12 (5.85%) | 7 (5.00%) | 5 (7.69%) | 0.525 | 205 |
COPD/bronchiectasis | 18 (8.78%) | 13 (9.29%) | 5 (7.69%) | 0.912 | 205 |
Asthma | 12 (5.85%) | 9 (6.43%) | 3 (4.62%) | 0.756 | 205 |
Immunologic disease | 4 (1.95%) | 2 (1.43%) | 2 (3.08%) | 0.593 | 205 |
Hospital admission | |||||
Days from the firsts symptoms | 7.00 [5.00; 9.00] | 7.00 [5.00; 9.00] | 6.00 [4.00; 8.00] | 0.088 | 205 |
Laboratory data | |||||
Urea nitrogen mg/dL | 46.5 [32.0; 65.8] | 48.0 [33.5; 61.2] | 44.5 [31.8; 71.0] | 0.881 | 200 |
Creatinine mg/dL | 0.92 [0.76; 1.16] | 0.92 [0.75; 1.13] | 0.94 [0.78; 1.27] | 0.469 | 204 |
C-reactive protein mg/dL | 151 [87.3; 211] | 155 [91.8; 239] | 116 [68.5; 181] | 0.020 | 195 |
White blood count × 109/L | 7.27 [5.53; 10.2] | 8.07 [6.04; 10.9] | 6.12 [4.91; 8.11] | 0.002 | 205 |
Hemoglobin g/dL | 13.8 [12.6; 14.9] | 13.6 [12.6; 14.9] | 13.9 [12.4; 14.9] | 0.671 | 205 |
Platelet count × 109/L | 200 [154; 245] | 206 [162; 244] | 183 [142; 246] | 0.094 | 204 |
Lymphocyte count × 109/L | 0.75 [0.56; 1.02] | 0.75 [0.55; 1.01] | 0.72 [0.63; 1.02] | 0.443 | 205 |
International normalized ratio (INR) | 1.13 [1.07; 1.21] | 1.13 [1.09; 1.24] | 1.12 [1.05; 1.18] | 0.058 | 195 |
D-dimer mg/L | 345 [225; 617] | 369 [246; 686] | 283 [214; 429] | 0.028 | 164 |
Arterial blood gas | |||||
pH | 7.45 [7.39; 7.48] | 7.44 [7.36; 7.47] | 7.46 [7.43; 7.49] | 0.002 | 182 |
Partial pressure of oxygen (PaO2) | 66.0 [53.0; 90.0] | 68.0 [54.0; 94.0] | 61.5 [52.8; 81.0] | 0.098 | 181 |
Partial pressure of carbon dioxide (PaCO2) | 34.0 [31.0; 40.0] | 35.0 [31.0; 41.2] | 32.5 [30.0; 36.0] | 0.003 | 180 |
Oxygen saturation (O2 Sat) | 94.0 [89.9; 97.2] | 94.2 [89.9; 97.4] | 93.7 [90.0; 96.8] | 0.310 | 196 |
PaO2 to FiO2 ratio | 200 [128; 257] | 176 [115; 238] | 233 [160; 283] | 0.004 | 187 |
APACHE score at ICU admission | 14.0 [11.0; 18.0] | 16 [13; 21] | 12 [10; 15] | < 0.001 | 147 |
Pharmacological treatment | |||||
Hydroxychloroquine | 68 (33.2%) | 61 (43.6%) | 7 (10.8%) | < 0.001 | 205 |
Corticosteroids | 189 (92.2%) | 124 (88.6%) | 65 (100%) | 0.011 | 205 |
Anticoagulant | 192 (93.7%) | 129 (92.1%) | 63 (96.9%) | 0.234 | 205 |
Antibiotics | 191 (93.6%) | 135 (96.4%) | 56 (87.5%) | 0.027 | 204 |
Lopinavir/ritonavir | 68 (33.2%) | 61 (43.6%) | 7 (10.8%) | < 0.001 | 205 |
Remdesivir | 27 (13.2%) | 16 (11.5%) | 11 (16.9%) | 0.400 | 204 |
Tocilizumab | 129 (62.9%) | 77 (55.0%) | 52 (80.0%) | 0.001 | 205 |