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Table 3 Incidence of invasive pulmonary aspergillosis

From: Invasive pulmonary aspergillosis among intubated patients with SARS-CoV-2 or influenza pneumonia: a European multicenter comparative cohort study

 

SARS-CoV-2 pneumonia

n = 566

Influenza pneumonia

n = 481

Unadjusted cHR

(95% CI)

Adjusted cHR*

(95% CI)

p value*

Blot definition

     

Putative invasive pulmonary aspergillosis

14/566 (2.5)

29/481 (6.0)

3.07 (1.52 to 6.19)

3.29 (1.53 to 7.02)

0.0006

Putative invasive pulmonary aspergillosis or Aspergillus colonization

23/566 (4.1)

49/481 (10.2)

3.17 (1.87 to 5.35)

3.21 (1.88 to 5.46)

 < 0.0001

Verweij definition

     

Probable invasive pulmonary aspergillosis

17/566 (3.0)

41/481 (8.5)

3.54 (1.86 to 6.73)

3.78 (1.96 to 7.27)

 < 0.0001

  1. Values are number of invasive pulmonary aspergillosis (28-day cumulative incidence expressed as %, considering extubation (dead or alive) as a competing event)
  2. cHR calculated using cause-specific Cox’s proportional hazard model with sandwich covariance estimation to account for center clustering effect
  3. *Adjusted for pre-specified confounders (simplified acute physiology score II, chronic obstructive pulmonary disease, immunosuppression, recent antibiotic treatment, acute respiratory distress syndrome, corticosteroid treatment), and calculated after handling missing values on covariates by multiple imputation
  4. cHR, cause-specific hazard ratio; CI, confidence interval
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