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Fig. 1 | Critical Care

Fig. 1

From: Anti-influenza T cells in bronchoalveolar microenvironment of critically severe COVID-19 patients

Fig. 1

Influenza A-specific T cell clonotypes in the bronchoalveolar lavage fluid T cells from COVID-19 patients. A The analysis framework of the digitalized sorting of epitope-specific T cells. Epitope-specific T cells were sorted according to their antigenic-specific TCR-β sequence. In this study, influenza A-specific T cell clonotypes were defined by T cell clonotypes with influenza A-specific TCR-β sequence using single-cell RNA sequencing. B The donut plot shows the percentage of COVID-19 patients defined by the categories of influenza A-specific T cells and COVID-19 disease severity. The colors represent the COVID-19 patients with or without influenza A-specific T cells in bronchoalveolar lavage fluid T cells. C The percentage (%) of influenza A-specific T cells in bronchoalveolar T cells in COVID-19 patients with mild (n = 3), severe (n = 1), and critical (n = 5) disease severity, with color coding according to the specificity of T cells to different epitopes from different genes of influenza A virus. The “*” shows the epitopes that could be found to elicit T cell response

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