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Table 3 Association of long-term neuroendocrine abnormalities with long-term physical function 5-years after critical illness

From: Persisting neuroendocrine abnormalities and their association with physical impairment 5 years after critical illness

Outcome

β-estimate (95% CI)

p

Handgrip strength dominant hand

 T3/rT3 Z-score per unit added

2.372 (0.153; 4.592)

0.036

 IGFBP3 Z-score per unit added

2.158 (0.191; 4.126)

0.031

Handgrip strength non-dominant hand

 T3/rT3 Z-score per unit added

2.758 (0.257; 5.259)

0.030

 IGFBP3 Z-score per unit added

1.093 (− 1.138; 3.324)

0.33

6-min walk distance

 T3/rT3 Z-score per unit added

2.746 (0.551; 4.941)

0.014

 IGFBP3 Z-score per unit added

− 1.675 (− 3.625; 0.275)

0.092

Physical component score SF36

 T3/rT3 Z-score per unit added

0.905 (− 0.289; 2.098)

0.13

 IGFBP3 Z-score per unit added

− 0.277 (− 1.311; 0.758)

0.59

  1. Patients on chronic thyroid hormone, GHRH or somatostatin analogue treatment were excluded for these analyses. Models were adjusted for sex, and age and BMI at 5-year follow-up
  2. CI confidence interval, SF36 Medical Outcomes Report–Short Form 36