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Table 1 Participants’ demographics and physical function at 5-year follow-up

From: Persisting neuroendocrine abnormalities and their association with physical impairment 5 years after critical illness

Characteristic

Patients (n = 436)

Controls (n = 50)

p

Demographics at 5-year follow-up

 Male sex, no (%)

302 (69.3)

35 (70.0)

0.91

 Age (years), median (IQR)

61 (51–69)

61 (57–66)

0.51

 BMI (kg/m2), median (IQR)

27.3 (24.2–30.5)

26.4 (23.7–29.3)

0.30

Physical function at 5-year follow-up

 Univariable analysis

  Handgrip strength dominant hand (%pred), median (IQR)

93 (78–107)

104 (91–119)

< 0.0001

  Handgrip strength non-dominant hand (%pred), median (IQR)

100 (83–117)

114 (102–125)

0.0002

  6-min walk distance (%pred), median (IQR)

95 (80–106)

117 (107–125)

< 0.0001

  Physical component score SF36, median (IQR)

48 (38–55)

55 (51–58)

< 0.0001

 Multivariable analysisa

  Handgrip strength dominant hand (%pred), β-estimate (95% CI)

− 6.194 (− 9.369; − 3.019)

0.0001

 

  Handgrip strength non-dominant hand (%pred), β-estimate (95% CI)

− 5.401 (− 8.962; − 1.840)

0.0030

 

  6-min walk distance (%pred), β-estimate (95% CI)

− 11.151 (− 14.212; − 8.091)

< 0.0001

 

  Physical component score SF36, β-estimate (95% CI)

− 3.781 (− 5.326; − 2.235)

< 0.0001

 
  1. aβ-estimates are indicated for patients versus controls
  2. %pred percent of predicted, CI confidence interval, IQR interquartile range, SF36 Medical Outcomes Report–Short Form 36