Table 3 Characteristics of children by age quartiles
From: Mechanical power in pediatric acute respiratory distress syndrome: a PARDIE study
| Â | Age quartiles (years)a | |||
|---|---|---|---|---|
 < 0.5 | 0.5 – 2 | 2 – 8.3 |  ≥ 8.3 | |
n | 75 | 76 | 77 | 76 |
Patient characteristics | ||||
Central/South America | 13 (17.3%) | 5 (6.6%) | 11 (14.3%) | 5 (6.6%) |
Europe | 15 (20%) | 7 (9.2%) | 9 (11.7%) | 4 (5.3%) |
Asia/Australia | 6 (8%) | 4 (5.3%) | 6 (7.8%) | 0 (0%) |
North America | 41 (54.5%) | 60 (79%) | 51 (66.2%) | 67 (88.2%) |
Any comorbid condition | 38 (50.7%) | 39 (51.3%) | 49 (63.6%) | 49 (64.5%) |
Bronchopulmonary Dysplasia | 4 (5.3%) | 12 (15.8%) | 1 (1.3%) | 0 (0%) |
Prematurity (< 32 weeks EGA) | 10 (13.3%) | 14 (18.4%) | 4 (5.2%) | 1 (1.3%) |
Oncologic Disease | 0 (0%) | 2 (2.6%) | 7 (9.1%) | 12 (15.8%) |
Chronic Respiratory Disease | 6 (8.0%) | 24 (31.6%) | 21 (27.3%) | 22 (29.0%) |
Congenital Cardiac Disease | 9 (12.0%) | 13 (17.1%) | 6 (7.8%) | 3 (4.0%) |
Acquired Cardiac Disease | 7 (9.3%) | 12 (15.8%) | 4 (5.2%) | 6 (7.9%) |
Neuromuscular Disease | 4 (5.3%) | 8 (10.5%) | 20 (26.0%) | 20 (26.3%) |
PARDS characteristics | ||||
Direct Lung Injury | 58 (77.3%) | 62 (81.6%) | 54 (70.1%) | 40 (52.6%) |
Oxygenation Indexb | 7.0 (5.0, 11.3) | 7.4 (4.8, 13.8) | 8.1 (4.8, 13) | 7.3 (4.5, 13.7) |
NIV at Diagnosis | 1 (1.3%) | 5 (6.6%) | 9 (11.7%) | 14 (18.4%) |
Ventilator management parameters | ||||
Mechanical ventilation mode pressure controlled | 31 (41.3%) | 24 (31.6%) | 37 (48.1%) | 28 (36.8%) |
PRVC | 21 (28%) | 27 (35.5%) | 18 (23.4%) | 26 (34.2%) |
Volume controlled | 11 (14.7%) | 12 (17.1%) | 14 (18.2%) | 15 (19.7%) |
Multiple modes | 12 (16%) | 12 (15.8%) | 8 (10.4%) | 7 (9.2%) |
VT (ml/kg predicted body weight) | 6.5 (5.6, 8.5) | 7.5 (6.3, 8.6) | 7.7 (7.0, 8.9) | 7.9 (6.6, 9.7) |
PIP (cm H2O) | 27 (23, 31) | 28 (24, 31) | 25 (22, 30) | 28 (23, 32) |
Delta pressure (cm H2O) | 20 (17, 24) | 20 (15, 23) | 18 (14, 20) | 18 (14, 23) |
RR (bpm) | 30 (25, 35) | 26 (24, 30) | 20 (18, 25) | 18 (16, 21) |
PEEP (cm H2O) | 7 (6, 8) | 8 (7, 9) | 8 (7, 11) | 9 (7, 12) |
Mechanical power (J·min−1∙Kg−1 predicted body weight) | 0.47 (0.33, 0.66) | 0.48 (0.35, 0.69) | 0.36 (0.26, 0.52) | 0.35 (0.26, 0.48) |
Mechanical energy (J·Kg−1 predicted body weight) | 0.016 (0.011, 0.022) | 0.019 (0.014, 0.026) | 0.018 (0.013, 0.022) | 0.019 (0.015, 0.026) |
PCO2 (mm Hg)c | 56 (48, 66) | 50 (41, 56) | 43 (38, 52) | 40 (35, 46) |
pHc | 7.31 (7.25, 7.39) | 7.34 (7.26, 7.38) | 7.35 (7.29, 7.42) | 7.36 (7.31, 7.42) |
Outcomes | ||||
Length of ventilation (survivors) | 6.1 (4.5, 9.8) | 7.4 (4.1, 14.2) | 6.5 (4.0, 14.8) | 9 (3.7, 13) |
28-day VFD (IMV) | 21.0 (14.6, 23.4) | 18.5 (7.5, 23.5) | 19.4 (2.0, 23.3) | 18.2 (4.0, 23.8) |
28-day VFD (IMV and NIV) | 20.6 (14.0, 22.9) | 18.0 (5.3, 23.2) | 18.2 (0, 23.2) | 16.6 (0, 22.4) |
ICU Mortality | 9 (12%) | 13 (17.1%) | 14 (18.2%) | 13 (17.1%) |