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Fig. 3 | Critical Care

Fig. 3

From: 17α-Ethinyl estradiol-3-sulfate increases survival and hemodynamic functioning in a large animal model of combined traumatic brain injury and hemorrhagic shock: a randomized control trial

Fig. 3

Panel A depicts immunohistochemistry (IHC) data for 2 animals from the EE-3-SO4 and Placebo cohorts of both amyloid precursor protein (APP) and Immunoglobulin G (IgG) at the level of the caudate nucleus near the second ventricle. Panel B depicts box-and-scatter plots of immunohistochemistry data for EE-3-SO4 (filled circles) and Placebo (unfilled circles) cohorts for the percentage of cortical (Cort) pixels presenting as positive for staining in both APP and IgG, including at the level of the cerebellum (Cblm) for IgG. Panel C presents box-and-scatter plots for primary blood biomarkers of glial fibrillary acidic protein (GFAP), neurofilament light chain (NFL), and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) collected at baseline (Base), following drug/Placebo administration (35 m), and at the terminal experimental endpoint (Term; ~ 295 min post-traumatic brain injury). None of the main effects or interactions associated with the Group variable (EE-3-SO4 vs. Placebo) were significant following Bonferroni correction

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