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Fig. 2 | Critical Care

Fig. 2

From: 17α-Ethinyl estradiol-3-sulfate increases survival and hemodynamic functioning in a large animal model of combined traumatic brain injury and hemorrhagic shock: a randomized control trial

Fig. 2

Box-and-scatter plots depicting primary point-of-care (POC; Panel A) and invasive hemodynamic (Hemo; Panels B and C) markers for EE-3-SO4 (filled circles) and Placebo (unfilled circles) cohorts. Data points are presented at collection times corresponding to Table 1, with POC measurements (glucose, lactate, bicarbonate [HCO3]) occurring at baseline (Base), following drug/Placebo administration (35 m), at hour intervals post-trauma (85 m, 145 m, 205 m), and at the terminal experimental endpoint (Term; ~ 295 min post-traumatic brain injury). Primary hemodynamic markers (shock-index [SI] and pulse-pressure [PP]) were continuously collected over the course of the entire experiment (Panel B), with data points displayed for baseline, immediately post-traumatic brain injury (0 m), immediately post blood loss procedure (25 m), at hour intervals post-trauma (85 m and 145 m), and at the terminal endpoint. Panel C presents a smaller temporal window to capture the predicted rapid effects (5 and 20 min post-drug) of EE-3-SO4 administration (significant Group × Time interaction). The asterisk denotes significant Group × Time interaction for PP

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Critical Care

ISSN: 1364-8535