Skip to main content

Table 1 Baseline characteristics of the study participants

From: Impact of rewarming rate on interleukin-6 levels in patients with shockable cardiac arrest receiving targeted temperature management at 33 °C: the ISOCRATE pilot randomized controlled trial

 

0.25 °C/h rewarming rate

(n1 = 25)

0.50 °C/h rewarming rate

(n2 = 25)

Age (years)

66.2 [52.2; 72.4]

53.8 [48.2; 70.0]

Male sex

21 (84.0)

20 (80.0)

Charlson comorbidity indexa

3.0 [1.0; 4.0]

1.0 [0.0; 3.0]

McCabe score, n (%)

 Disease expected to become fatal within 5 y

6 (24.0)

3 (12.0)

 Disease expected to be fatal within 1 y

0 (0.0)

0 (0.0)

 No fatal disease or unknown

19 (76.0)

22 (88.0)

Activity level (Knaus chronic health status score), n (%)

 Normal health status

8 (32.0)

11 (44.0)

 Moderate activity limitation

15 (60.0)

13 (52.0)

 Severe activity limitation due to chronic disease

2 (8.0)

1 (4.0)

 Bedridden

0 (0.0)

0 (0.0)

 SAPS II

65.0 [50.0; 71.0]

66.0 [51.0; 71.0]

 History of any health condition

13 (52.0)

11 (44.0)

 History of heart disease

10 (40.0)

7 (28.0)

 History of pulmonary disease

5 (20.0)

6 (24.0)

Location at cardiac arrest

 Home

11 (44.0)

11 (44.0)

 Public place

11 (44.0)

13 (52.0)

 Hospitalb

3 (12.0)

1 (4.0)

 Bystander-witnessed cardiac arrest

23 (92.0)

25 (100.0)

 Bystander performed CPR

21 (84)

20 (80.0)

Rhythm at cardiac arrest

 Ventricular fibrillation

20 (80)

24 (96.0)

 Ventricular tachycardia

4 (16.0)

1 (4.0)

Cause of cardiac arrest

 Cardiac cause

23 (92.0)

24 (96.0)

 Drowning

0 (0.0)

1 (4.0)

 Asphyxia

2 (8.0)

0 (0.0)

 Glasgow Coma Scale score at enrollmentc

3 [3; 3]

3 [3; 5]

 Corneal reflex present,

n1 = 21, n2 = 17

15 (71.4)

11 (64.7)

 Pupillary reflex present on the left,

n1 = 25, n2 = 24

19 (76.0)

20 (83.3)

 Pupillary reflex present on the right,

n1 = 24, n2 = 24

18 (75.0)

18 (75.0)

 ST-segment elevation myocardial infarction, n1 = 21, n2 = 19

11 (52.4)

14 (73.7)

 Attempted coronary revascularization

11 (44.0)

18 (72.0)

 Successful coronary revascularization

10 (40.0)

18 (72.0

 Circulatory shockd

14 (56.0)

14 (56.0)

 Serum pH,

n1 = 25, n2 = 23

7.25 [7.18; 7.33]

7.32 [7.24; 7.36]

 Lactate, mmol/L,

n1 = 25, n2 = 23

2.5 [1.6; 4.3]

2.4 [1.1; 3.4]

 No-flow duratione, minutes

0.0 [0.0; 2.0]

1.0 [0.0; 3.0]

 Low-flow durationf, minutes

20.0 [15.0; 30.0]

20.0 [10.0; 30.0]

 Epinephrine injection performed, n (%)

15 (60.0)

15 (60.0)

 Epinephrine dose, mg, median [IQR], mg,

n1 = 15, n2 = 15

3.0 [1.0; 4.0]

3.0 [1.0; 4.0]

 Duration from cardiac arrest to randomization, hours

26.6 [25.0; 28.1]

26.5 [25.2; 27.6]

 Body temperature at inclusion, °C

35.0 ± 1.0

35.0 ± 0.9

 CAHP scoreg

145.9 [107.4; 167.1]

133.1 [93.8; 170.1]

  1. The data are n (%) or median [25th; 75th percentiles]
  2. aCharlson comorbidity index: Each comorbidity category is weighted from 1 to 6, based on the adjusted risk of mortality or resource use, and the sum of the weights produces the score for the patient. A score of zero indicates absence of known comorbidities. Higher scores indicate higher risks of death and greater resource use
  3. bFour patients experienced cardiac arrest shortly after arrival at emergency rooms of community hospitals, achieved the ROSC, and were then immediately transferred to the study ICU
  4. cScores on the Glasgow Coma Scale can range from 3 to 15, with lower scores indicating worse consciousness impairment
  5. dCirculatory shock was defined as a systolic blood pressure of less than 90 mmHg for at least 30 min or impaired end-organ perfusion (cool extremities, mottling, urine output < 30 mL per hour)
  6. eNo-flow duration was time from collapse to basic life-support initiation
  7. fLow-flow duration was time from basic life-support initiation to return of spontaneous circulation
  8. gThe Cardiac Arrest Hospital Prognosis score is designed for the early stratification of patients admitted to the ICU after out-of-hospital cardiac arrest. Three risk groups are identified according to whether the score is ≤ 150, 150–200, or ≥ 200, with higher scores indicating a worse prognosis
Back to article page

Critical Care

ISSN: 1364-8535