Table 1 Patient characteristics in the full cohort of patients with septic shock and/or IMV requirements and in the propensity score matching sample
From: Real-world corticosteroid use in severe pneumonia: a propensity-score-matched study
Variable | Before PS matching (N = 387 | After PS matching (N = 178) | ||||
|---|---|---|---|---|---|---|
Corticosteroids | Corticosteroids | |||||
No | Yes | No | Yes | |||
N = 268 | N = 119 | p value | N = 89 | N = 89 | p value | |
Age (years), median (Q1; Q3) | 68.5 (54.5; 80) | 72 (59; 81) | 0.126 | 73 (56; 84) | 72 (59; 83) | 0.839 |
Male sex, n (%) | 115 (43) | 68 (57) | 0.010 | 50 (56) | 48 (54) | 0.763 |
Current smoking habit, n (%) | 86 (33) | 34 (30) | 0.489 | 27 (32) | 24 (28) | 0.616 |
Current alcohol abuse, n (%) | 37 (21) | 8 (13) | 0.190 | 10 (21) | 6 (13) | 0.273 |
Comorbidities, n (%) | ||||||
Diabetes mellitus | 63 (24) | 17 (14) | 0.033 | 15 (17) | 15 (17) | 1.000 |
Ischemic heart disease | 31 (18) | 21 (18) | 0.880 | 13 (15) | 13 (15) | 1.000 |
Hypertension | 64 (38) | 56 (47) | 0.110 | 36 (40) | 37 (42) | 0.879 |
COPD | 58 (22) | 41 (35) | 0.012 | 27 (30) | 27 (30) | 1.000 |
Cancer | 32 (12) | 25 (21) | 0.028 | 11 (12) | 13 (15) | 0.661 |
SOFA score, median (Q1; Q3) | 5 (3; 6) | 5 (4; 7) | 0.003 | 5 (4; 7) | 5 (3; 7) | 0.483 |
Pneumonia Severity Index, median (Q1; Q3) | 127.5 (107; 154.5) | 140 (119; 163) | 0.007 | 140 (121; 157) | 135 (116; 159) | 0.500 |
PaO2/FiO2 < 250, n (%) | 110 (42) | 70 (59) | 0.003 | 51 (44) | 51 (57) | 0.415 |
Altered mental status, n (%) | 83 (31) | 31 (26) | 0.296 | 39 (44) | 23 (26) | 0.010 |
Respiratory rate, median (Q1; Q3) | 28 (24; 32) | 26 (21; 30) | 0.058 | 28 (20; 35) | 25 (20; 30) | 0.276 |
Heart rate, median (Q1; Q3) | 110 (28; 95) | 100 (81; 114) | 0.004 | 107 (90; 130) | 98 (85; 111) | 0.034 |
Temperature (°C), median (Q1; Q3) | 37 (36.2; 38) | 37.4 (36.7; 38) | 0.161 | 37 (36.3; 38) | 37.4 (36.8; 38) | 0.092 |
Creatinine (mg/dL), median (Q1; Q3) | 1.4 (1; 1.9) | 1.2 (0.8; 1.6) | 0.001 | 1.3 (1; 1.9) | 1.1 (0.8; 1.6) | 0.032 |
CRP (mg/dl), median (Q1; Q3) | 29 (23.1; 37.1) | 30.3 (24.4; 44.1) | 0.274 | 29.4 (24.8; 37.3) | 30 (24.3; 43.9) | 0.961 |
White blood cell count (109 cells/L), median (Q1; Q3) | 12.6 (7.6; 19) | 14.6 (7.9; 20.9) | 0.259 | 12.8 (6.4; 17.9) | 16 (9.2; 20.7) | 0.131 |
Need of IMV, n (%) | 134 (52) | 50 (42) | 0.073 | 42 (50) | 32 (36) | 0.062 |
Septic shock, n (%) | 197 (74) | 107 (90) | 0.001 | 74 (83) | 79 (89) | 0.281 |
Polymicrobial infection, n (%) | 8 (3) | 10 (8) | 0.020 | 4 (4) | 8 (9) | 0.232 |
Initial appropriate treatment, n (%) | 237 (92) | 97 (88) | 0.319 | 78 (88) | 85 (96) | 0.059 |