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Table 2 Changes in respiratory mechanics and gas exchange at 5 and 15 cmH2O of PEEP between high and low respiratory system compliance group

From: Positive end-expiratory pressure in COVID-19 acute respiratory distress syndrome: the heterogeneous effects

Variables

Low Crs

 < 44 mL/cmH2O

30 patients

High Crs

≥ 44 mL/cmH2O

31 patients

p

Δ15-5 Plateau pressure, cmH2O

10 [7–12]

11 [10–13]

0.042

Δ15-5 Driving pressure, cmH2O

0 [− 3 to 2]

1 [0–3]

0.042

Δ15-5 Respiratory system elastance, cmH2O/L

− 1 [− 5 to 4]

2 [0–6]

0.057

Δ15-5 Lung elastance, cmH2O/L

2 [− 2 to 5]

2 [0–5]

0.286

Δ15-5 Chest wall elastance, cmH2O/L

0 [− 2 to 2]

0 [− 1 to 0]

0.305

Δ15-5 Lung stress, cmH2O

9 [6–11]

9 [8–12]

0.256

Δ15-5 Mechanical power, J/min

9 [8–12]

9 [8–11]

0.866

Δ15-5 Mechanical Power_Compliancers, J/min/(mL/cmH2O)

0.26 [0.12–0.40]

0.23 [0.16–0.35]

0.656

Δ15-5 PaO2, mmHg

20 [13–38]

20 [6–30]

0.336

Δ15-5 PaO2/FiO2, mmHg

28 [16–51]

30 [10–50]

0.657

Δ15-5 Right-to-left shunt, %

− 12 [− 23 to − 1]

− 9 [− 18 to − 5]

0.710

Δ15-5 PvO2, mmHg

4.0 [2.3–8.8]

2.0 [1.0–8.1]

0.219

Δ15-5 ScvO2, %

5.5 [1.0–10.8]

2.5 [0.0–8.1]

0.184

Δ15-5 Ca-vO2, mL

1.0 [0.3–1.7]

0.6 [0.2–1.3]

0.331

Δ15-5 PaCO2, mmHg

1 [− 1 to 3]

2 [1–4]

0.226

Δ15-5 Ventilatory ratio

0.04 [− 0.10 to 0.10]

0.08 [0.02–0.20]

0.119

Δ15-5 Estimated physiological dead space

0.01 [− 0.01 to 0.03]

0.02 [0.01–0.05]

0.119

  1. T-test or Wilcoxon–Mann–Whitney test were performed, as appropriate. Δ15-5: difference between 15 and 5 cmH2O of PEEP; Ca-vO2: arterial–venous oxygen content difference; Compliancers: respiratory system compliance; ScvO2 central oxygen venous saturation; PvO2 mixed venous oxygen tension