Fig. 1

a Box plots of plasma endocan values during hemodialysis. Box plots show median, 1st and 3rd quartiles, and whiskers at 1.5-time interquartile range. Comparisons between paired values were performed using Friedman test. b Variations of plasma endocan relatively to values measured at T0. Comparisons between values at each time point with T0 value were performed using Wilcoxon-signed ranks test. c Values of endocan expressed in ng/ml at each time point. Patients are shown in yellow rows in case of hemodialysis with EVODIAL membranes and blue rows in case of ELISIO membranes. We used a linear mixed model with type of membrane set as fix effect and timing of blood collection set as random effect to assess the effect of the type of membrane on variations of endocan during hemodialysis. Plasma endocan was measured at the Immunology Institute of Lille Teaching Hospital, France, using the ENDOMARK H1 ELISA kit (Biothelis, France). T0: sampling within 1 h before start of hemodialysis. T1: sampling 30–60 min after start of hemodialysis. T2: sampling 90–120 min after start of hemodialysis. T3: sampling 180–240 min after start of hemodialysis. T4: sampling 90–120 min after end of hemodialysis. All statistical tests were two-tailed, and p values < 0.05 were considered statistically significant. All data analyses were performed using R, version 3.6 (R Foundation for Statistical Computing, Austria). *p < 0.05. **p < 0.01. ns: non-significant