Fig. 2

Axial view of brain computed tomography (CT) scan of a 63-year-old man who was hospitalized and treated for 107 days for sepsis due to soft tissue infection. A and B are the first CT scan and C and D are the second CT scan of the patient. A and C are original brain CT scans and B and D are brain CT scans with a corresponding segmentation map where gray and white matter are colored red. Compared to the first CT scan (A), atrophy is evident on the second CT scan (C). Although small misclassifications are observed in the cerebellar vermis (arrows on B and D) and the right choroid plexus (white arrowhead on B), automatic segmentation was successful. Subtle beam-hardening artifact is found around the posterior fossa (red arrowheads on C),; it did not affect the classification. A 7.4% decrease in brain volume was calculated by the automatic algorithm