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Table 1 Characteristics of patients with septic shock according to leucocyte telomere length at day 1 (n = 55)

From: Telomere shortening during human septic shock: influence of sepsis mediators, role in organ failures, and septic myocardial dysfunction

  Lower LTL (n = 27) Higher LTL (n = 28) P value
Clinical characteristics and comorbidities
Age (years) 64 [53–74] 64 [49–72] 0.60
Male gender, n (%) 20 (74%) 12 (43%) 0.02
Chronic obstructive pulmonary disease 0 (%) 1 (4%) > 0.99
Chronic kidney disease requiring long-term dialysis 2 (7%) 2 (7%) 0.97
Liver cirrhosis 4 (15%) 3 (11%) > 0.99
Mc Cabe and Jackson class 0.49
 0 11 (39%) 12 (43%)  
 1 10 (37%) 13 (46%)  
 2 6 (21%) 3 (11%)  
SAPS II at ICU admission 50 [41–79] 59 [39–79] 0.83
Community acquired infection 13 (48%) 16 (57%) 0.50
Lung source of infection 14 (52%) 13 (46%) 0.69
Bacteraemia 11 (41%) 13 (46%) 0.67
Surgery 6 (27%) 4 (16%) 0.48
Organ failures
Sequential organ failure assessment score 10 [8–13] 11 [8–13] 0.83
Arterial lactates (mmol/L) 2.9 [1.5–5.5] 2.9 [1.4–4.9] 0.87
PaO2/FiO2 ratio (mmHg) 164 [115–350] 188 [109–260] 0.79
Serum creatinine (mmol/L) 201 [84–338] 164 [84–264] 0.35
Septic myocardial dysfunction 10 (37%) 9 (32%) 0.70
Outcome
Mechanical ventilation 25 (93%) 24 (86%) 0.67
Dialysis for acute renal failure 6 (22%) 4 (14%) 0.50
ARDS 18 (67%) 13 (46%) 0.18
ICU acquired infection 12 (43%) 9 (32%) 0.41
Death in ICU 15 (55%) 13 (46%) 0.49
Death in hospital 15 (55%) 16 (46%) > 0.99
  1. The telomere repeat copy number to single-gene copy number (T/S) ratio was determined using the comparative Ct method (T/S = 2−ΔΔCt) with 36B4 gene for normalization (acidic ribosomal phosphoprotein PO, a single-copy gene). Data are number (percentage) or median [first quartile-third quartile]
  2. LTL leucocyte telomere length, SAPS simplified acute physiology score, PaO2 partial pressure of oxygen in arterial blood, FiO2 fraction of inspired oxygen, ARDS acute respiratory distress syndrome, ICU intensive care unit