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Table 1 Characteristics of articles

From: A systematic review and meta-analysis of enrollment into ARDS and sepsis trials published between 2009 and 2019 in major journals

Characteristic Number Percent
Included studies 94  
Target patient population   
Acute respiratory distress syndrome (ARDS)/acute lung injury (ALI) 23 24.5
Sepsis (includes sepsis, severe sepsis, septic shock) 67 71.3
Both sepsis and ARDS 4 4.3
Publication period   
2009–2013 43 45.7
2014–2019 51 54.3
Journal   
American Journal of Respiratory and Critical Care Medicine 9 9.6
Chest 1 1.1
Critical Care 14 14.9
Critical Care Medicine 16 17.0
Intensive Care Medicine 11 11.7
Journal of the American Medical Association 18 19.1
Journal of the American Medical Association – Internal Medicine 1 1.1
Lancet 2 2.1
Lancet—Respiratory Medicine 2 2.1
New England Journal of Medicine 20 21.3
Continent of first author   
Asia 8 8.5
Australia 4 4.3
Europe 46 48.9
North America 21 22.3
South America 15 16.0
Funding sourcesa   
Academic institution 19 20.2
Association or foundation 14 14.9
Government 47 50.0
Industry 21 22.3
Unreported 9 9.6
Interventionb   
Clinical protocol 32 34.0
Device 12 12.8
Diagnostic test 1 1.1
Drug 50 53.2
Consent type   
Prospective 76 80.9
Retrospective 18 19.1
Enrollment achievedc (N = 90)   
\(\ge\) 95% of target sample size enrolled 54 60
 < 95% of target sample size enrolled 36 40
Futilitya 15 41.6
Safetya 10 27.8
Efficacya 4 11.1
Slow enrollmenta 8 22.2
Other/not reporteda 4 11.1
  1. aNot mutually exclusive, bOne article reported both a pharmacotherapeutic and clinical protocol intervention, cFour trials did not report a sample size target