From: Prolonged time from intubation to cannulation in VV-ECMO for COVID-19: does it really matter?
Total cohort | ECMO survivors | ECMO non-survivors | p | |
---|---|---|---|---|
n = 56 | n = 27 | n = 29 | ||
General characteristics | ||||
Age (Years) | 57 (51–65) | 56 (50–60) | 60 (55–66) | 0.036 |
Male gender | 49 (88) | 23 (85) | 26 (90) | 0.7 |
BMI (kg/m2) | 30 (27–34) | 33 (29–36) | 28 (27–34) | 0.09 |
Comorbidities | ||||
Hypertension | 29 (52) | 15 (56) | 14 (48) | 0.61 |
Diabetes | 16 (29) | 6 (22) | 10 (35) | 0.38 |
Pre-ECMO care | ||||
Time from first symptom to ECMO (days) | 18 (10–22) | 18 (10–20) | 18 (13–25) | 0.22 |
Time from intubation to ECMO (days) | 6 (4–13) | 6 (1–13) | 6 (4–10) | 0.41 |
Prone position | 56 (100) | – | – | – |
Neuromuscular blockers | 56 (100) | – | – | – |
Ventilation parameters at cannulation time | ||||
Tidal volume (mL/kg of PBW) | 5.9 (5.5–6.1) | 5.7 (5.4–6) | 5.9 (5.5–6.1) | 0.55 |
PEEP (cmH2O) | 10 (6–14) | 10 (7–14) | 10 (5–14) | 0.73 |
P Plat (cm H2O) | 31 (30–34) | 31 (30–35) | 31 (30–32) | 0.80 |
Compliance of RS (mL/cm H2O) | 20 (15–23) | 20 (14–24) | 19 (15–24) | 0.87 |
Gazometric parameters at cannulation time | ||||
pH | 7.29 (7.23–7.36) | 7.30 (7.25–7.37) | 7.28 (7.23–7.36) | > 0.99 |
PaO2/FiO2 (mm Hg) | 62 (53–74) | 60 (53–67) | 62 (55–75) | 0.38 |
PaCO2 (mm Hg) | 63 (52–73) | 64 (55–70) | 62 (50–75) | > 0.99 |
SOFA score at cannulation time | ||||
Total SOFA score | 7 (4–8) | 7(4–8) | 7 (4–10) | 0.75 |
SOFA score excluding respiratory item | 3 (0–4) | 3 (0–4) | 3 (1–6) | 0.49 |
General evolution | ||||
ECMO duration (days) | 18 (10–31) | 18 (8–31) | 17 (12–32) | 0.85 |
ICU duration (days) | 46 (28–60) | 59 (47–75) | 31 (23–43) | < 0.01 |
ECMO complications | 29 (52) | – | – | – |
Bleeding | 48 (86) | 20 (74) | 28 (97) | 0.023 |
Infections | 37 (66) | 18 (67) | 19 (66) | > 0.99 |
Hemolysis | 19 (34) | 10 (37) | 9 (31) | 0.78 |
Death causes n (% of non-survivors) | ||||
Bleeding | – | – | 12 (41) | |
Sepsis | – | – | 10 (35) | |
End-of-life decision | – | – | 4 (14) |