Table 1 Summary characteristics of included trials
No. of trials n = 234 | No. of participants n = 102,681 | |
|---|---|---|
Trial characteristics | ||
Multicenter study | 26 | 80,268 |
Single-center study | 208 | 22,413 |
Patient disease type | ||
Trauma (including traumatic brain injury) | 7 | 34,488 |
Obstetrics and gynecology | 22 | 28,089 |
Cardiac surgery | 47 | 10,528 |
Orthopedic surgery | 124 | 11,353 |
Intracranial (non-traumatic) hemorrhage | 9 | 4057 |
Gastrointestinal hemorrhage | 3 | 12,312 |
Others | 22 | 1854 |
Patient characteristics | ||
Mean age (year) of trial arms, median [IQR] | Control: 54 [43–66] Intervention: 50 [46–67] | |
Percentage of female patients in trial arms, median [IQR] | Control: 54 [35–70] Intervention: 53 [31–73] | |
Adults | 225 | 101,917 |
Pediatrics | 9 | 764 |
TXA dose | ||
≦ 2 g/day | 180 | 78,268 |
2 g/day < TXA dose ≦ 4 g/day | 14 | 13,887 |
> 4 g | 20 | 7603 |
Composite | 20 | 2923 |
TXA regimen | ||
Bolus administration | 149 | 47,973 |
Continuous infusion | 4 | 785 |
Bolus + infusion | 80 | 53,848 |