Table 2 Estimated odds ratios (ORs) and confidence intervals of important variables in a multivariate logistic model predicting the onset of hypoglycemia (blood glucose ≤ 70 mg/dL) within 6 h
From: The obesity paradox and hypoglycemia in critically ill patients
| Odds ratio (CI) | Full data | Sensitivity analysis | Diabetes adjusted |
|---|---|---|---|
| BMI [0–18.5] kg/m2 |
1.6 (1.43–1.79) |
1.61 (1.28–2.03) |
1.58 (1.35–1.86) |
| BMI [18.5–25] kg/m2 |
1 (–) |
1 (–) |
1 (–) |
| BMI [25–30] kg/m2 |
0.72 (0.67–0.77) |
0.74 (0.65–0.85) |
0.68 (0.62–0.74) |
| BMI [30–35] kg/m2 |
0.65 (0.6–0.71) |
0.63 (0.52–0.76) |
0.59 (0.53–0.66) |
| BMI [35–40] kg/m2 |
0.61 (0.54–0.69) |
0.46 (0.32–0.65) |
0.58 (0.5–0.66) |
| BMI > 40 kg/m2 |
0.53 (0.46–0.61) |
0.83 (0.48–1.41) |
0.44 (0.38–0.51) |
| Blood glucose [70–108] mg/dL |
1 (–) |
1 (–) |
1 (–) |
| Blood glucose [108–144] mg/dL |
0.3 (0.28–0.32) |
0.26 (0.22–0.29) |
0.34 (0.31–0.37) |
| Blood glucose [144–180] mg/dL |
0.26 (0.24–0.28) |
0.18 (0.15–0.21) |
0.34 (0.3–0.38) |
| Blood glucose > 180 mg/dL |
0.29 (0.26–0.32) |
0.18 (0.15–0.22) |
0.35 (0.31–0.39) |
| Insulin = 0 u/h |
1 (–) |
1 (–) |
1 (–) |
| Insulin [0–2.5] u/h |
2.18 (2.01–2.35) |
3.02 (2.58–3.52) |
1.32 (1.17–1.49) |
| Insulin [2.5–5] u/h |
5.07 (4.69–5.48) |
6.97 (5.87–8.28) |
3.47 (3.12–3.87) |
| Insulin > 5 u/h |
6.41 (5.87–7) |
8.76 (7.11–10.79) |
4.17 (3.73–4.66) |
| Blood lactate [0–2] mmol/L |
1 (–) |
1 (–) |
1 (–) |
| Blood lactate [2–5] mmol/L |
1.6 (1.48–1.73) |
1.45 (1.25–1.7) |
1.8 (1.62–2) |
| Blood lactate > 5 mmol/L |
3.24 (2.86–3.68) |
3.79 (3.03–4.74) |
3.63 (3.03–4.35) |
| MAP ≥ 60 mmHg, no vasopressor therapy |
1 (–) |
1 (–) |
1 (–) |
| MAP < 60 mmHg or vasopressor therapy |
1.48 (1.39–1.57) |
1.41 (1.24–1.6) |
1.56 (1.43–1.69) |
| Parenteral nutrition |
0.66 (0.58–0.76) |
0.68 (0.52–0.89) |
0.75 (0.61–0.92) |
| Enteral nutrition |
0.83 (0.78–0.89) |
0.62 (0.55–0.71) |
1.11 (1.02–1.21) |
| Corticosteroids |
0.85 (0.77–0.94) |
0.81 (0.67–0.98) |
0.95 (0.84–1.08) |
| Dextrose 10% 0 mL/h |
1 (–) |
1 (–) |
1 (–) |
| Dextrose 10% < 25 mL/h |
1.06 (0.74–1.52) |
0.8 (0.37–1.72) |
1.03 (0.69–1.56) |
| Dextrose 10% > 25 mL/h |
2.04 (1.75–2.37) |
2 (1.57–2.55) |
1.92 (1.51–2.44) |
| Diabetes | – | – |
2.21 (2.04–2.4) |
| SOFA* |
1.07 (1.06–1.08) |
1.04 (1.01–1.06) |
1.07 (1.06–1.09) |
| AUMC |
1 (–) |
1 (–) | – |
| HiRID |
0.43 (0.39–0.48) |
0.66 (0.58–0.74) | – |
| MIMIC–III |
0.92 (0.86–0.99) | – |
1 (–) |
| eICU |
1.51 (1.38–1.65) | – |
2.19 (2–2.4) |