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Table 2 Estimated odds ratios (ORs) and confidence intervals of important variables in a multivariate logistic model predicting the onset of hypoglycemia (blood glucose ≤ 70 mg/dL) within 6 h

From: The obesity paradox and hypoglycemia in critically ill patients

Odds ratio (CI) Full data Sensitivity analysis Diabetes adjusted
BMI [0–18.5] kg/m2 1.6
(1.43–1.79)
1.61
(1.28–2.03)
1.58
(1.35–1.86)
BMI [18.5–25] kg/m2 1
(–)
1
(–)
1
(–)
BMI [25–30] kg/m2 0.72
(0.67–0.77)
0.74
(0.65–0.85)
0.68
(0.62–0.74)
BMI [30–35] kg/m2 0.65
(0.6–0.71)
0.63
(0.52–0.76)
0.59
(0.53–0.66)
BMI [35–40] kg/m2 0.61
(0.54–0.69)
0.46
(0.32–0.65)
0.58
(0.5–0.66)
BMI > 40 kg/m2 0.53
(0.46–0.61)
0.83
(0.48–1.41)
0.44
(0.38–0.51)
Blood glucose [70–108] mg/dL 1
(–)
1
(–)
1
(–)
Blood glucose [108–144] mg/dL 0.3
(0.28–0.32)
0.26
(0.22–0.29)
0.34
(0.31–0.37)
Blood glucose [144–180] mg/dL 0.26
(0.24–0.28)
0.18
(0.15–0.21)
0.34
(0.3–0.38)
Blood glucose > 180 mg/dL 0.29
(0.26–0.32)
0.18
(0.15–0.22)
0.35
(0.31–0.39)
Insulin = 0 u/h 1
(–)
1
(–)
1
(–)
Insulin [0–2.5] u/h 2.18
(2.01–2.35)
3.02
(2.58–3.52)
1.32
(1.17–1.49)
Insulin [2.5–5] u/h 5.07
(4.69–5.48)
6.97
(5.87–8.28)
3.47
(3.12–3.87)
Insulin > 5 u/h 6.41
(5.87–7)
8.76
(7.11–10.79)
4.17
(3.73–4.66)
Blood lactate [0–2] mmol/L 1
(–)
1
(–)
1
(–)
Blood lactate [2–5] mmol/L 1.6
(1.48–1.73)
1.45
(1.25–1.7)
1.8
(1.62–2)
Blood lactate > 5 mmol/L 3.24
(2.86–3.68)
3.79
(3.03–4.74)
3.63
(3.03–4.35)
MAP ≥ 60 mmHg, no vasopressor therapy 1
(–)
1
(–)
1
(–)
MAP < 60 mmHg or vasopressor therapy 1.48
(1.39–1.57)
1.41
(1.24–1.6)
1.56
(1.43–1.69)
Parenteral nutrition 0.66
(0.58–0.76)
0.68
(0.52–0.89)
0.75
(0.61–0.92)
Enteral nutrition 0.83
(0.78–0.89)
0.62
(0.55–0.71)
1.11
(1.02–1.21)
Corticosteroids 0.85
(0.77–0.94)
0.81
(0.67–0.98)
0.95
(0.84–1.08)
Dextrose 10% 0 mL/h 1
(–)
1
(–)
1
(–)
Dextrose 10% < 25 mL/h 1.06
(0.74–1.52)
0.8
(0.37–1.72)
1.03
(0.69–1.56)
Dextrose 10% > 25 mL/h 2.04
(1.75–2.37)
2
(1.57–2.55)
1.92
(1.51–2.44)
Diabetes 2.21
(2.04–2.4)
SOFA* 1.07
(1.06–1.08)
1.04
(1.01–1.06)
1.07
(1.06–1.09)
AUMC 1
(–)
1
(–)
HiRID 0.43
(0.39–0.48)
0.66
(0.58–0.74)
MIMIC–III 0.92
(0.86–0.99)
1
(–)
eICU 1.51
(1.38–1.65)
2.19
(2–2.4)
  1. Rows corresponding to referent value bins are italicized
  2. ALT, alanine aminotransferase; AST, aspartate aminotransferase; h, hours; IU, international units; MAP, mean arterial pressure; mL, milliliters u/h units per hour
  3. *SOFA score without cardio component