Univariate OR (95% CI) | P value | Multivariate OR (95% CI) | P value | |
---|---|---|---|---|
Age, years | < 0.001 | 0.078 | ||
≤ 75 | – | – | ||
60–74 | 0.98 (0.72–1.32) | 1.74 (0.93–3.28) | ||
40–59 | 0.58 (0.43–0.80) | 1.33 (0.68–2.64) | ||
< 40 | 0.45 (0.27–0.74) | 0.54 (0.14–1.82) | ||
Genre, woman | 0.73 (0.58–0.92) | 0.009 | 0.72 (0.44–1.19) | 0.203 |
Body mass index, kg/m2 | – | 0.870 | – | 0.178 |
< 25 | ||||
25–29 | 1.05 (0.79–1.40) | 0.89 (0.51–1.55) | ||
30–34 | 1.18 (0.86–1.63) | 1.58 (0.83–3.01) | ||
35–39 | 1.14 (0.76–1.72) | 1.01 (0.45–2.26) | ||
≥ 40 | 1.05 (0.60–1.85) | 2.42 (0.73–8.26) | ||
Active smokers | 1.00 (0.61–1.63) | 0.996 | 0.83 (0.31–2.20) | 0.701 |
SAPS II score | 1.05 (1.04–1.06) | < 0.001 | 1.07 (1.04–1.09) | < 0.001 |
Treated hypertension | 1.35 (1.10–1.66) | 0.004 | 0.79 (0.51–1.23) | 0.300 |
Known diabetes | 1.31 (1.05–1.65) | 0.019 | 0.74 (0.45–1.20) | 0.222 |
Immunodepressiona | 1.43 (0.95–2.15) | 0.085 | 0.85 (0.32–2.23) | 0.747 |
Frailty score | 0.009 | – | 0.875 | |
1–3 | – | |||
4 | 1.70 (1.16–2.51) | 1.27 (0.51–3.32) | ||
5–9 | 1.46 (0.93–2.31) | 1.07 (0.37–3.04) | ||
Delay between first signs and ICU admission, days | < 0.001 | – | 0.012 | |
< 4 | – | |||
4–7 | 0.84 (0.58–1.20) | 0.74 (0.35–1.53) | ||
≥ 8 | 0.44 (0.31–0.62) | 0.42 (0.20–0.87) | ||
During the first 24 h in ICU | ||||
Oxygenation technique | 0.019 | 0.013 | ||
Standard oxygen | – | – | ||
HFNC | 0.98 (0.79–1.21) | 0.60 (0.36–0.99) | ||
NIV | 1.60 (1.13–2.27) | 1.57 (0.78–3.21) | ||
Cardiovascular component of the SOFA score ≥ 3 | 3.37 (1.75–7.00) | < 0.001 | 1.45 (0.37–7.53) | 0.608 |
Renal component of the SOFA score ≥ 3 | 1.06 (0.68–1.66) | 0.785 | 0.35 (0.12–0.99) | 0.048 |
Corticosteroidsb | 0.76 (0.55–1.05) | 0.096 | 0.93 (0.46–1.88) | 0.847 |
pH | 0.12 (0.02–0.71) | 0.010 | 0.95 (0.02–59.91) | 0.980 |
PaCO2, mmHg | 1.00 (1.00–1.00) | 0.856 | 0.97 (0.94–1.00) | 0.064 |
PaO2/FiO2c, mmHg | < 0.001 | – | < 0.001 | |
≤ 100 | – | |||
101–200 | 0.43 (0.33–0.55) | 0.32 (0.20–0.50) | ||
201–300 | 0.26 (0.17–0.37) | 0.21 (0.10–0.41) | ||
> 300 | 0.25 (0.15–0.43) | 0.23 (0.07–0.71) | ||
HCO3, mmol/L | 0.97 (0.94–0.99) | 0.006 | 1.00 (0.97–1.03) | 0.993 |
Lactate, mmol/L | 1.31 (1.12–1.57) | < 0.001 | 1.28 (1.06–1.67) | 0.001 |
Lymphocyte count < 1 × 109/L | 1.59 (1.26–2.01) | < 0.001 | 1.20 (0.79–1.85) | 0.394 |
Platelet count < 150 × 109/L | 1.76 (1.32–2.37) | < 0.001 | 1.16 (0.65–2.06) | 0.621 |
Total bilirubin concentration, µmol/L | 1.00 (0.99–1.01) | 0.990 | 1.00 (0.97–1.02) | 0.769 |
ICU admission period, March 29 to May 4, 2020 | 0.63 (0.51–0.77) | < 0.001 | 0.46 (0.29–0.72) | < 0.001 |