Skip to main content

Table 3 Factors at ECMO onset associated with 90-day mortality of severe COVID-19–ARDS patients on ECMO

From: Evolving outcomes of extracorporeal membrane oxygenation support for severe COVID-19 ARDS in Sorbonne hospitals, Paris

Factor Univariate HR (95% CI) p Multivariate HR (95% CI) a p
Date of ICU admission   0.110   0.050
 Before July 1   
 After July 1 1.47 (0.92–2.37)   2.27 (1.02–5.07)  
Age, years    < 0.001   0.006
 ˂45   
 45–55 2.81 (1.26–6.29)   1.86 (0.74–4.65)  
 ˃55 5.13 (2.39–11.00)   3.55 (1.48–8.50)  
Days from ICU admission to ECMO   0.017   0.066
  < 4 days   
 4–7 days 1.37 (0.69–2.74)   2.51 (1.04–6.10)  
 8–10 days 1.50 (0.68–3.29)   2.83 (1.04–7.70)  
  > 10 days 2.82 (1.43–5.57)   3.02 (1.15–7.92)  
Driving pressure pre-ECMO, cmH2O   0.150   0.264
  < 17   
 17–20 0.95 (0.45–1.99)   0.84 (0.37–1.94)  
 20–22 1.18 (0.57–2.42)   1.04 (0.47–2.29)  
 ˃22 1.98 (1.03–3.81)   1.85 (0.86–3.98)  
PaO2/FiO2 pre-ECMO   0.621   0.815
  < 53   
 53–61 0.80 (0.42–1.53)   1.08 (0.49–2.39)  
 61–69 0.82 (0.42–1.61)   0.77 (0.33–1.81)  
 ˃69 1.19 (0.62–2.27)   1.12 (0.48–2.62)  
PaCO2 pre-ECMO, mmHg   0.007   0.066
  < 0   
 50–57 0.72 (0.31–1.67)   0.79 (0.30–2.13)  
 57–66 1.64 (0.82–3.30)   2.10 (0.91–4.86)  
 ˃66 2.35 (1.20–4.59)   2.11 (0.98–4.53)  
Dexamethasone started pre-ECMO 1.07 (0.67–1.71) 0.783 0.37 (0.17–0.79) 0.012
SOFA score CV component ≥ 3 1.82 (1.13–2.94) 0.013 2.44 (1.31–4.55) 0.004
SOFA score renal component ≥ 3 1.58 (0.87–2.89) 0.156 1.50 (0.72–3.13) 0.296
  1. CV cardiovascular, SOFA sequential organ failure assessment, ICU intensive care unit, HR hazard ratio, CI confidence interval
  2. aComplete analysis of 55 patients