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Table 3 Mixed linear analysis for time-integrated mean arterial pressure (MAP) area (mmHg min) between the lower and upper MAP bounds for maintained cerebrovascular reactivity (CVR) and total MAP area below the lower and above the upper MAP bound for maintained CVR stratified by the factorial design groups during three time periods: 0–12 h, 12–24 h and 24–48 h, with good or poor neurologic outcomes

From: Association of deranged cerebrovascular reactivity with brain injury following cardiac arrest: a post-hoc analysis of the COMACARE trial

 

0–12 h

12–24 h

24–48 h

p-value

MAP area between lower and upper MAP bounds, mmHg min

    

All patients

5399 (3950–8231)

7958 (4818–11079)

15870 (9423–21785)

 

Good outcome

6900 (4849–8880)

8389 (5166–11479)

17277 (10180–22792)

0.246

Poor outcome

5542 (3292–6903)

6134 (3500–9262)

12139 (6305–16794)

 

MAP area below lower MAP bound, mmHg min

    

All patients

132 (36–479)

107 (31–305)

235 (6–653)

 

Good outcome

118 (33–358)

103 (28–319)

235 (54–503)

0.061

Poor outcome

150 (46–502)

134.6 (54.2–358.3)

197 (85–1153)

 

MAP area above upper MAP bound, mmHg min

    

All patients

315 (100–846)

195 (55–1004)

266 (99–101)

 

Good outcome

319 (96–800)

135 (28–338)

222 (79–1011)

0.243

Poor outcome

314 (108–1369)

253 (64–10492)

339 (149–1010)

 
  1. Values are expressed as medians (interquartile ranges)