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Table 3 Mixed linear analysis for time-integrated mean arterial pressure (MAP) area (mmHg min) between the lower and upper MAP bounds for maintained cerebrovascular reactivity (CVR) and total MAP area below the lower and above the upper MAP bound for maintained CVR stratified by the factorial design groups during three time periods: 0–12 h, 12–24 h and 24–48 h, with good or poor neurologic outcomes

From: Association of deranged cerebrovascular reactivity with brain injury following cardiac arrest: a post-hoc analysis of the COMACARE trial

  0–12 h 12–24 h 24–48 h p-value
MAP area between lower and upper MAP bounds, mmHg min     
All patients 5399 (3950–8231) 7958 (4818–11079) 15870 (9423–21785)  
Good outcome 6900 (4849–8880) 8389 (5166–11479) 17277 (10180–22792) 0.246
Poor outcome 5542 (3292–6903) 6134 (3500–9262) 12139 (6305–16794)  
MAP area below lower MAP bound, mmHg min     
All patients 132 (36–479) 107 (31–305) 235 (6–653)  
Good outcome 118 (33–358) 103 (28–319) 235 (54–503) 0.061
Poor outcome 150 (46–502) 134.6 (54.2–358.3) 197 (85–1153)  
MAP area above upper MAP bound, mmHg min     
All patients 315 (100–846) 195 (55–1004) 266 (99–101)  
Good outcome 319 (96–800) 135 (28–338) 222 (79–1011) 0.243
Poor outcome 314 (108–1369) 253 (64–10492) 339 (149–1010)  
  1. Values are expressed as medians (interquartile ranges)