Table 2 Mixed linear model analysis for Mean TOx, OptTOx, OptMAP, upper and lower MAP bounds and MAP range for maintained CVR in three time periods: 0–12 h, 12–24 h and 24–48 h
Group | 0–12 h | 12–24 h | 24–48 h | p-value | |
|---|---|---|---|---|---|
Mean TOx | Poor outcome | 0.06 (− 0.07 to 0.14) | − 0.03 (− 0.11 to 0.16) | 0.01 (− 0.09 to 0.14) | 0.004 |
Good outcome | − 0.04 (− 0.12 to 0.04) | − 0.05 (− 0.21 to 0.05) | − 0.02 (− 0.10 to 0.06) | ||
OptTOx | Poor outcome | − 0.21 (− 0.35 to − 0.02) | − 0.17 (− 0.36 to − 0.02) | − 0.19 (− 0.36 to − 0.05) | 0.077 |
Good outcome | − 0.24 (− 0.38 to − 0.14) | − 0.27 (− 0.48 to − 0.10) | − 0.23 (− 0.37 to − 0.11) | ||
OptMAP | Poor outcome | 79.7 (73.5–87.8) | 76.4 (71.1–81.7) | 81.7 (72.4–88.3) | 0.079 |
Good outcome | 80.9 (71.4–86.7) | 81.7 (73.0–87.4) | 82.7 (75.0–87.4) | ||
Upper MAP bound | Poor outcome | 90.5 (81.1–98.4) | 89.5 (80.6–92.9) | 92.8 (83.4–100.3) | 0.001 |
Good outcome | 94.7 (85.4–102.3) | 93.4 (83.2–100.4) | 94.4 (89.0–101.0) | ||
Lower MAP bound | Poor outcome | 69.6 (64.2–74.4) | 66.2 (63.0–73.1) | 68.5 (63.4–74.4) | 0.569 |
Good outcome | 68.0 (63.3–75.9) | 69.7 (62.1–74.7) | 68.4 (63.6–73.5) | ||
MAP range | Poor outcome | 19 (15–30) | 24 (17–26) | 23 (17–29) | < 0.001 |
Good outcome | 28 (23–36) | 25 (20–36) | 33 (25–39) |