Table 1 Characteristics and outcomes of patients with Covid-19 related acute respiratory distress syndrome, with or without acute cor pulmonale
From: Acute cor pulmonale in Covid-19 related acute respiratory distress syndrome
N patients with data | All patients (n = 117) | No ACP (n = 73) | ACP (n = 44) | p value | |
|---|---|---|---|---|---|
Patient characteristics | |||||
Age (years) | 117 | 62.0 ± 10.3 | 63.2 ± 9.9 | 60.2 ± 10.9 | 0.132 |
Male gender | 117 | 94 (80%) | 60 (82%) | 34 (77%) | 0.517 |
Body mass index (kg/m2) | 113 | 29.06 ± 5.69 | 28.27 ± 5.69 | 30.34 ± 5.50 | 0.061 |
SAPS II | 116 | 36 [28–46] | 37 [30–47] | 34 [27–46] | 0.249 |
SOFA score (Day 1) | 117 | 5 [4–8.5] | 5 [4–9] | 5 [4–8] | 0.503 |
Medical history | |||||
Diabetes | 117 | 47 (40%) | 36 (49%) | 11 (25%) | 0.009 |
Arterial Hypertension | 117 | 69 (59%) | 47 (64%) | 22 (50%) | 0.125 |
Heart failure (NYHA III-IV) | 117 | 9 (8%) | 8 (11%) | 1 (2%) | 0.150 |
Chronic kidney disease | 117 | 19 (16%) | 17 (23%) | 2 (5%) | 0.008 |
Chronic obstructive pulmonary disease | 117 | 11 (9%) | 7 (10%) | 4 (9%) | 0.929 |
Respiratory parameters* | |||||
pH | 112 | 7.36 [7.31–7.41] | 7.36 [7.31–7.42] | 7.38 [7.33–7.41] | 0.366 |
PaCO2 (mmHg) | 112 | 42 [38–47] | 42 [38–47] | 44 [39–48] | 0.313 |
P/F ratio | 116 | 132 [95–177] | 135 [96–175] | 129 [91–189] | 0.869 |
PEEP (cmH2O) | 110 | 11 [9–12] | 11 [8.75–12] | 11.5 [9–12] | 0.869 |
Driving Pressure (cmH2O) | 100 | 12 [10–15] | 13 [11–15] | 12 [10–14] | 0.108 |
Tidal Volume (mL/kg) | 86 | 6.0 [5.7–6.4] | 6.1 [5.9–6.4] | 5.9 [5.6–6.5] | 0.37 |
Respiratory Rate (/min) | 83 | 30 [26–32] | 28 [25–32] | 30 [28–34] | 0.126 |
Respiratory-system compliance (mL/cmH2O) | 102 | 35 [28–40] | 34 [27–40] | 37 [29–44] | 0.089 |
ARDS ACP risk score | |||||
Pneumonia as cause of ARDS | 117 | 117 (100%) | 73 (100%) | 44 (100%) | > 0.99 |
Driving pressure ≥ 18 cmH2O | 100 | 11 (9%) | 9 (12%) | 2 (5%) | 0.192 |
P/F < 150 | 116 | 77 (66%) | 46 (63%) | 31 (70%) | 0.468 |
PaCO2 ≥ 48 mmHg | 112 | 27 (23%) | 16 (22%) | 11 (25%) | 0.773 |
Total ACP risk score (0–4) | 97 | 2 [1–2.5] | 0.978 | ||
Laboratory data** | |||||
Platelets (109/L) | 115 | 244 [182–303] | 244 [182–298] | 243 [189–312] | 0.92 |
Fibrinogen (g/L) | 94 | 6.82 ± 1.72 | 6.95 ± 1.65 | 6.62 ± 1.83 | 0.379 |
D-dimer (ng/mL) | 84 | 1948 [1140–4205] | 1948 [1249–2956] | 2335 [1006–8660] | 0.551 |
CT-scan data | |||||
Thorax CT angiography*** | 117 | 81 (69%) | 54 (74%) | 27 (61%) | 0.431 |
Pulmonary embolism | 81 | 9 (8%) | 2 (3%) | 7 (16%) | 0.007 |
ICU and outcome data**** | |||||
Prone position | 117 | 107 (91%) | 64 (88%) | 43 (98%) | 0.087 |
Shock | 117 | 91 (78%) | 55 (75%) | 36 (82%) | 0.414 |
Nitrous oxide use | 117 | 26 (22%) | 14 (19%) | 12 (27%) | 0.308 |
Tracheotomy | 117 | 19 (16%) | 8 (11%) | 11 (25%) | 0.046 |
VV-ECMO | 117 | 22 (19%) | 10 (14%) | 12 (27%) | 0.069 |
Ventilation days (survivors) | 71 | 17 [10–38] | 15 [8–34] | 22 [11–42] | 0.395 |
Ventilator-free days at D28 | 115 | 0 [0–13] | 0 [0–15] | 0 [0–13] | 0.516 |
D28 all-cause mortality | 117 | 44 (38%) | 29 (40%) | 15 (34%) | 0.542 |