Identification of persistent and resolving subphenotypes of acute hypoxemic respiratory failure in two independent cohorts

Table 2 Relative risk of mortality associated with persistent hypoxemic respiratory failure

	Deaths	Relative risk (95% confidence interval)
	N (%)	Unadjusted	Model A	Model B
Discovery cohort
Resolving	31 (8%)	1.00 (reference)	1.00 (reference)	1.00 (reference)
Persistent	77 (20%)	2.46 (1.66, 3.64)^a	2.34 (1.56, 3.49)^a	1.68 (1.11, 2.54)^b
Validation cohort
Resolving	70 (10%)	1.00 (reference)	1.00 (reference)	1.00 (reference)
Persistent	230 (22%)	2.17 (1.69, 2.79)^a	2.08 (1.58, 2.76)^a	1.93 (1.50, 2.47)^a

Mortality is in-hospital mortality 28 days after enrollment
Model A: adjusted for age, sex, chronic respiratory disease, and PaO₂-to-FIO₂ ratio on enrollment
Model B: adjusted for age, sex, chronic respiratory disease, and modified acute physiology and chronic health evaluation on enrollment (APACHE-III score in discovery cohort and APACHE-II score in validation cohort)
^ap < 0.001 ^bp < 0.05

ISSN: 1364-8535