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Table 1 Multi-morbidity clusters in old patients and associated MODS risk profiles

From: The management of multi-morbidity in elderly patients: Ready yet for precision medicine in intensive care?

Known condition Associated/(hidden) conditions MODS risk profile
Hypertension CHF, metabolic syndrome AKI, arrhythmia, stroke
Coronary disease CHF, CKD, carotid stenosis, PVD MI/CHF, arrhythmia, stroke, AKI
COPD Pulmonary hypertension RVF, arrhythmia, AKI
Diabetes Coronary disease, PVD, CKD MI/CHF, AKI, stroke, infection, gastroparesis
Geriatric conditions (examples)
 Frailty CHF, CKD, sarcopenia, dementia, sensory impairment AKI, weaning failure, delirium, pressure sores, malnutrition
 Polypharmacy CKD, arrhythmia, coagulopathy, electrolyte disturbances AKI, CHF, intracranial bleed, delirium
 Chronic pain Osteoporosis, sarcopenia and immobility masking coronary artery disease / CHF, polypharmacy AKI, HF, delirium, malnutrition
  1. AKI: acute kidney injury; CHF: congestive heart failure; CKD: chronic kidney disease; COPD: chronic obstructive pulmonary disease; HF: heart failure; MI: myocardial infarction; MODS: multiple organ dysfunction syndrome; PVD: peripheral vascular disease; RVF: right ventricular failure