PEEP Strategy | phenotype-I | phenotype-II | phenotype-III |
|---|
Low PEEP (n = 108) | High PEEP (n = 115) | Low PEEP (n = 97) | High PEEP (n = 82) | Low PEEP (n = 68) | High PEEP (n = 79) |
|---|
60-day mortality | 14.8% | 22.6% | 28.9% | 28.1% | 35.3% | 34.2% |
Ventilator-free days | 18.0 | 15.5 | 12.1 | 12.3 | 10.7 | 11.3 |
ICU-free days | 16.1 | 14.2 | 9.9 | 10.8 | 9.1 | 10.4 |
- For test of interaction, 60-day mortality of phenotype-I versus II p = 0.25, phenotype-I versus III p = 0.25, phenotype-II versus III p = 0.99; ventilator-free days (VFD) of phenotype-I versus II p = 0.002, phenotype-I versus III p = 0.001, phenotype-II versus III p = 0.67; ICU-free days (IFD) of phenotype-I versus II p < 0.001, phenotype-I versus III p < 0.001, phenotype-II versus III p = 0.47. VFD: number of days during the 28-day period where patients are both alive and free of mechanical ventilation; IFD: number of days during the 28-day period where patients are both alive and free of ICU care; ALVEOLI, randomized controlled trials of higher versus lower PEEP; PEEP, positive end-expiratory pressure; ICU, intensive care unit
