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Table 1 Characteristics of the study cohort

From: Inhaled liposomal amphotericin-B as a prophylactic treatment for COVID-19-associated pulmonary aspergillosis/aspergillus tracheobronchitis

  Overall (n = 50) Standard of care (n = 18) Inhaled amphotericin-B (n = 32) p-value
Baseline characteristics
Age 65.5 (10.8) 64.8 (13.0) 65.9 (9.62) 0.75a
Male sex 37 (74.0%) 17 (94.4%) 20 (62.5%) 0.02b
Immunocompromized state 15 (30.0%) 7 (38.9%) 8 (25.0%) 0.30c
Cancer (incl. hematological) 13 (26.0%) 5 (27.8%) 8 (25.0%)  
Immunosuppressive or HIV medication 6 (12.0%) 2 (11.1%) 4 (12.5%)  
Organ transplant 1 (2.0%) 0 (0%) 1 (3.1%)  
Primary immunoglobulin G deficiency 2 (4.0%) 2 (11.1%) 0 (0%)  
Other comorbidities     
Diabetes mellitus 26 (52.0%) 8 (44.4%) 18 (56.2%) 0.42c
Arterial hypertension 26 (52%) 6 (33.3%) 20 (62.5%) 0.02c
Heart failure (NYHA ≥ 2) 2 (4.4%) 1 (5.6%) 1 (3.1%) 1b
Chronic kidney disease without dialysis 5 (10%) 2 (11.1%) 3 (9.4%) 1b
Chronic dialysis 3 (6%) 1 (5.6%) 2 (6.3%) 1b
Modified frailty index [6] 0.16 (0.12) 0.12 (0.11) 0.18 (0.13) 0.14 a
Admission characteristics
PaO2/FiO2 at admission 111 (76–136) 91 (73–147) 113 (81–136) 0.41d
SOFA score at admission 5.5 (4–8) 7 (4–8) 5 (4–8) 0.51 d
SAPS-3 score 55.7 (17.7) 54.0 (12.0) 54.6 (14.1) 0.68 a
Time from hospital admission to intubation (days) 3.5 (1–10) 5.5 (1–16) 3 (1–10) 0.51 d
Time from ICU admission to intubation (days) 2 (0–7) 1.5 (0–8) 2 (0–5) 0.67 d
Vasopressor use 48 (96%) 16 (88.9%) 32 (100%) 0.05 c
Renal replacement therapy (incl. chronic dialysis) 20 (40%) 9 (50.0%) 11 (34.4%) 0.28 c
COVID-19 treatment
Dexamethasone 33 (66.0%) 9 (50.0%) 24 (75.0%) 0.07 c
Tocilizumab 8 (16.0%) 2 (11.1%) 6 (18.8%) 0.69 b
  1. Numbers are presented as means (standard deviation), n (%) or medians (interquartile range) as appropriate. Test statistics: a = independent samples t-test; b = Fisher’s exact test; c = Chi square test; d = Mann–Whitney test
  2. NYHA = New York Heart Association; SAPS = simplified acute physiology score; SOFA = sequential organ assessment score; ICU = intensive care unit; COVID-19 = Coronavirus Disease of 2019