Table 2 Laboratory findings and ventilation management of the early ventilated patients at day 3 according to in-hospital mortality
No | All patients (n = 1118) | Survivors (n = 685) | Non-survivors (n = 433) | p-value | |
|---|---|---|---|---|---|
Arterial blood gases | |||||
PaO2/FiO2 ratio, mmHg | 1054 | 180.0 [135.4–227.9] | 190.0 [148.6–237.5] | 158.0 [114.0–208.7] | < 0.001 |
PaO2/FiO2 ratio categories | 1054 | ||||
PaO2/FiO2 ratio < 100 mmHg | 98 (9.3%) | 36 (5.6%) | 63 (15.2%) | < 0.001 | |
PaO2/FiO2 ratio ≥ 100 and < 200 mmHg | 550 (52.2%) | 317 (49.4%) | 233 (56.6%) | 0.023 | |
PaO2/FiO2 ratio ≥ 200 and < 300 mmHg | 313 (29.7%) | 232 (36.1%) | 81(19.7%) | < 0.001 | |
PaO2/FiO2 ratio ≥ 300 mmHg | 91 (8.6%) | 56 (8.7%) | 35 (8.5%) | 1.00 | |
pH | 1082 | 7.39 [7.33–7.44] | 7.40 [7.35–7.45] | 7.37 [7.30–7.41] | < 0.001 |
PaCO2, mmHg | 1090 | 47.0 [41.8–54.0] | 46.0 [40.0–51.0] | 50.3 [44.0–58.0] | < 0.001 |
Lactate, mg/dL | 756 | 15.3 [11.7–20.1] | 15.3 [11.1–19.8] | 16.6 [12.6–20.7] | 0.001 |
Laboratory findings | |||||
Lymphocyte count, 109/L | 1090 | 0.64 [0.41–1.00] | 0.70 [0.48–1.00] | 0.60 [0.38–0.90] | < 0.001 |
Neutrophil count, 109/L | 472 | 7.58 [5.60–10.50] | 7.40 [5.24–10.29] | 8.10 [6.10–10.5] | 0.030 |
Platelet count, 109/L | 1095 | 255.0 [189.0–325.0] | 274.0 [206.5–340.0] | 222.5 [168.8–293.0] | < 0.001 |
D-dimers, mg/L | 754 | 2.31 [1.05–6.52] | 1.97 [0.96–4.76] | 3.27 [1.39–8.92] | < 0.001 |
Ferritin, ng/mL | 345 | 1326 [835–2200] | 1308 [790–2144] | 1361 [839–2244] | 0.50 |
IL6, pg/mL | 115 | 98.0 [43.1–196.6] | 81.0 [44.4–191.0] | 125.9 [41.7–196.9] | 0.51 |
CRP, mg/dL | 925 | 10.0 [3.4–22.6] | 9.3 [3.1–20.7] | 10.8 [3.8–23.5] | 0.09 |
Bilirubin, mg/dL | 957 | 0.75 [0.42–1.30] | 0.75 [0.42–1.26] | 0.76 [0.42–1.35] | 0.71 |
Serum creatinine, mg/dL | 1101 | 0.92 [0.67–1.39] | 0.81 [0.62–1.17] | 1.10 [0.78–1.88] | < 0.001 |
Ventilatory setting and pulmonary mechanics | |||||
Tidal volume/PBW (ml/kg) | 926 | 7.3 [6.5–8.1] | 7.3 [6.5–8.1] | 7.3 [6.5–8.1] | 0.81 |
Respiratory rate, rpm | 1006 | 22.0 [18.0–24.0] | 21.0 [18.0–24.0] | 22.0 [20.0–25.0] | 0.003 |
PEEP, cmH2O | 1051 | 12.0 [10.0–14.0] | 12.0 [10.0–14.0] | 12.0 [10.0–14.0] | 0.46 |
FiO2, % | 1065 | 50.0 [40.0–60.0] | 50.0 [40.0–60.0] | 60.0 [50.0–70.0] | < 0.001 |
Peak inspiratory pressure, cmH2O | 537 | 30.0 [27.0–35.0] | 30.0 [27.8–34.6] | 33.0 [27.0–36.0] | 0.11 |
End-inspiratory plateau pressure, cmH2O | 413 | 24.0 [21.0–28.0] | 24.0 [21.0–27.0] | 25.0 [22.0–29.0] | 0.001 |
Driving pressure, cmH2Oa | 401 | 12.0 [10.0–15.0] | 12.0 [9.5–14.0] | 12.2 [10.0–16.0] | 0.022 |
Compliance, mL/cmH2Ob | 399 | 37.5 [28.8–48.0] | 38.4 [30.0–48.3] | 34.6 [25.1–46.6] | 0.032 |
Ventilatory ratioc | 905 | 1.96 [1.61–2.40] | 1.86 [1.53–2.24] | 2.11 [1.77–2.68] | < 0.001 |
Position | 967 | ||||
Supine | 658 (68.0%) | 451 (74.0%) | 219 (58.6%) | < 0.001 | |
Prone | 285 (29.5%) | 138 (23.3%) | 145 (38.8%) | < 0.001 | |
Other | 24(2.5%) | 16 (2.7%) | 9 (2.4%) | 0.84 | |