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Table 3 Multivariable logistic regression model for major adverse kidney events at the time of hospital discharge by renin tertiles

From: Serum renin and major adverse kidney events in critically ill patients: a multicenter prospective study

Variable

Odds ratio with 95% confidence intervala

p value

Renin tertile (vs. first tertile)

 Second tertile

2.51 (1.08–5.80)

0.032

 Third tertile

2.33 (1.01–5.44)

0.050

Age (vs. first quartile)

 Second quartile

0.32 (0.12–0.86)

0.023

 Third quartile

0.31 (0.10–0.95)

0.040

 Fourth quartile

0.30 (0.08–1.11)

0.071

Sex (male vs. female)

0.63 (0.32–1.25)

0.188

Race (vs. white)

 Black

2.30 (0.74–7.15)

0.150

 Other

1.20 (0.39–3.68)

0.748

Baseline eGFR, per 1 ml/min/1.73 m2

1.02 (0.99–1.04)

0.173

Charlson comorbidity index, per 1-unit

1.64 (1.35–2.00)

< 0.001

ICU (vs. surgical)

 Medical

2.82 (1.30–6.12)

0.009

 Cardiac

2.12 (0.69–6.48)

0.189

Site (UK vs. UTSW)

1.28 (0.54–3.02)

0.572

Non-renal APACHE II, per 1-unit

1.02 (0.98–1.06)

0.246

NGAL, per 1-log unit

2.93 (2.02–4.23)

< 0.001

  1. eGFR estimated glomerular filtration rate, ICU intensive care unit, UK University of Kentucky, UTSW University of Texas Southwestern, APACHE II Acute Physiology and Chronic Health Evaluation II, NGAL neutrophil gelatinase-associated lipocalin
  2. aFixed model developed using hypothesized predictors of outcome and clinically relevant imbalances in renin tertiles