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Table 2 Haemodynamic variables during the study protocol

From: Norepinephrine potentiates the efficacy of volume expansion on mean systemic pressure in septic shock

 

High dose of NE

Low dose of NE

Baseline

PLR

Baseline

PLR

SAP (mmHg)

141 [25]

146 [25]

120 [17] b

127 [23]c

DAP (mmHg)

60 [9]

63 [11]a

54 [7]b

58 [8]c

MAP (mmHg)

88 [12]

94 [13]

76 [8]b

80 [10]c

Heart rate (beats/min)

93 [16]

96 [15]

92 [14]

96 [14]

CVP (mmHg)

13.0 [5.0]

15.8 [5.8]a

12.4 [5.2]

14.3 [5.9]c

Pms (mmHg)

30.7 [10.3]

35.6 [11.2]a

27.7 [9.7]b

30.5 [10.4]c

Pms-PVC (mmHg)

17.6 [9.8]

19.7 [11.2]

15.3 [9.7]b

16.2 [9.8]

Indexed venous resistance (mmHg.min.m2/L)

5.4 [2.7]

5.5 [2.9]

4.9 [2.7]

4.7 [2.3]

Indexed arterial resistance (mmHg.min.m2/L)

17.7 [8.3]

16.4 [10.0]a

15.6 [6.1]b

14.4 [6.1]

Cardiac index (L/min/m2)

3.24 [0.9]

3.57 [0.9]a

3.08 [0.7]b

3.43 [0.8]c

Dose of NE (μg/kg/min)

0.32 [0.2–0.6]

0.32 [0.2–0.6]

0.26 [0.1–0.5]b

0.26 [0.1–0.5]

Cardiac function index (/min)

4.8 [1.3]

 

4.9 [1.5]

 
  1. N = 30. Data are expressed as mean [standard deviation]
  2. CVP, central venous pressure; DAP, diastolic arterial pressure; MAP, mean arterial pressure; NE, norepinephrine, Pms, mean systemic pressure; SAP, systolic arterial pressure
  3. ap < 0.05 PLR at high dose vs. baseline at high dose
  4. bp < 0.05 baseline at low dose vs. baseline at high dose
  5. cp < 0.05 baseline at low dose vs. PLR at low dose