Pancreatic stone protein for early mortality prediction in COVID-19 patients

Table 1 Characteristics of study participants at inclusion in the emergency department according to 7-day mortality

Patients characteristics	Survival (n = 161; 93%)	Death (n = 12; 7%)	p value
Sex: female, n (%)	102 (63.4)	5 (41.7)	0.236
Age (y), years [IQR]	64.0 [52.0, 75.0]	81.50 [70.3, 83.3]	0.001
Any comorbidities, n (%)	110 (68.3)	11 (91.7)	0.169
Hypertension, n (%)	73 (45.3)	8 (66.7)	0.259
Diabetes, n (%)	39 (24.2)	5 (41.7)	0.320
Obesity, n (%)	18 (11.7)	1 ( 9.1)	1.000
Cardiovascular disease, n (%)	20 (12.4)	6 (50.0)	0.002
Neurologic disease, n (%)	14 ( 8.7)	5 (41.7)	0.002
Symptoms duration, days [IQR]	7 [4, 10]	4 [3, 8]	0.140
Respiratory rate, r/min [IQR]	24 [20, 28]	34 [25, 40.00]	0.001
Heart rate median, b/min[IQR]	85 [77, 96]	96 [90, 103]	0.034
Systolic blood pressure, mmHg [IQR]	133 [122, 144]	126 [115, 145]	0.459
qSOFA ≥ 2, n (%)	3 (1.9)	3 (25.0)	< 0.001
CRB-65 ≥ 2, n (%)	18 (11.2)	9 (75.0)	< 0.001
CRP (mg/l), [IQR]	75.0 [31.0, 140.0]	205.5 [147, 254.8]	< 0.001
PSP (ng/ml), [IQR]	70.0 [48.0, 104.0]	141.0 [98.8, 224.0]	< 0.001
Outpatient management, n (%)	38 (23.6)	0 (0)	0.071
7-day intermediate care unit admission, n (%) *	12 (7.5)	3 (25)	0.072
7-day intensive care unit admission, n (%)	33 (20.5)	4 (33.3)	0.295

Quick Sepsis-related Organ Failure Assessment (qSOFA): 1 point each for systolic hypotension (≤ 100 mm Hg), tachypnea (≥ 22/min), or altered mentation (Glasgow Coma Scale score ≤ 14); CRB-65: 1 point each for Confusion (Glasgow Coma Scale score ≤ 14), elevated Respiratory rate (≥ 30/min), low Blood pressure (systolic < 90 mm Hg or diastolic ≤ 60 mm Hg), age 65 years or more. CRP C-reactive protein; PSP pancreatic stone protein. IQR interquartile range
^*Not including patients who went to the intermediate and the intensive care units within 7 days of inclusion

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