Table 1 PICOS criteria for inclusion of studies
Parameter | Inclusion criteria |
|---|---|
Population | Adult (age ≥ 18 years old) critically ill patients (mechanically ventilated or mortality of > 5% in the control group) |
Intervention | Higher protein delivery through enteral formula, enteral protein supplementation, parenteral nutrition, or intravenous amino acids |
Comparator | Lower protein delivery (similar calories delivery with the intervention group) |
Outcomes | Clinical outcomes (mortality, infectious complication, duration of mechanical ventilation, length of ICU stay, length of hospital stay) and/or patient-centered outcomes (muscle mass, muscle strength, physical function, discharge destination and quality of life) |
Study design | Randomized controlled trial |