Skip to main content
Fig. 1 | Critical Care

Fig. 1

From: Altered cholesterol homeostasis in critical illness-induced muscle weakness: effect of exogenous 3-hydroxybutyrate

Fig. 1

Effect of 3-hydroxybutyrate on plasma cholesterol concentrations and correlations with muscle force. Septic mice received parenteral nutrition supplemented with 3-hydroxybutyrate (3HB) or isocaloric glucose as placebo (plcb). a Plasma total cholesterol concentrations. b Plasma free cholesterol concentrations. c Plasma esterified cholesterol concentrations. d Correlation between absolute maximal muscle force and plasma esterified cholesterol concentrations. Gray line and spread represent fit. Absolute maximal muscle force was previously quantified in the extensor digitorum longus (EDL) muscle with ex vivo muscle force measurements [5] [White: healthy control (ctrl) mice, n = 15; orange: septic mice receiving placebo, n = 17; green: septic mice receiving 3HB, n = 17]. Data in boxplots represent median and interquartile range; dots represent outliers. §p ≤ 0.05, §§p ≤ 0.001 between healthy controls and septic mice, *p ≤ 0.05, **p ≤ 0.01, between groups of septic mice

Back to article page