Authors | Sample size and setting | Primary diagnosis | Study design and risk of bias | Intervention | Rate control outcome | Rhythm control outcome | Mortality outcome |
---|---|---|---|---|---|---|---|
Delle Karth et al. (2001) | n = 60 n = 20 (diltiazem) n = 20 (amiodarone bolus) n = 20 (amiodarone bolus and 24 h infusion) Setting: Austria ICU | Mixed cardiac and medical ICU population | RCTa Risk of bias: high | Diltiazem versus amiodarone bolus versus amiodarone bolus and 24 h continuous infusion | Rate reduction within 4 h: NSb Diltiazem: 70% Amiodarone bolus: 55% Amiodarone bolus with 24 h continuous infusion: 75% Rate reduction within 24 h: Diltiazem versus amiodarone groups: p = .001 Amiodarone bolus versus amiodarone bolus with 24 h continuous infusion: p = .08 | Within 4 h: NS Diltiazem: 30% Amiodarone bolus: 40% Amiodarone bolus with 24 h continuous infusion: 45% | Not assessed |
Gerlach et al. (2008) | n = 61 n = 55 NOAF patients n = 28 (diltiazem) n = 27 (amiodarone) Setting: USA Surgical ICU | Noncardiac surgical population | Prospective comparative Risk of bias: Critical | Diltiazem versus amiodarone | Not assessed | At 24 h: NS Diltiazem: 87% Amiodarone: 87% Mean time to conversion: NS Diltiazem: 7 h Amiodarone: 5 h | Not assessed |
Jaffer et al. (2016) (conference abstract) | n = 65 Setting: USA ICU | Septic shock | Retrospective comparative Risk of bias: Critical | Calcium channel blockers (drug not specified) versus amiodarone | Not assessed | Not assessed | NS |
Mieure et al. (2011) (conference abstract) | n = 126c n = 61 (amiodarone) n = 41 (diltiazem) Setting: USA ICU | Not reported | Retrospective comparative Risk of bias: Critical | Diltiazem versus amiodarone | At 24 h: NS Diltiazem: 85% Amiodarone: 85% | Diltiazem: 7% Amiodarone: 21% | Not assessed |
McKenzie Brown et al. (2018) | n = 33d n = 6 (amiodarone) n = 2 (calcium channel blockers) Setting: USA Surgical ICU | Noncardiac surgical population | Retrospective comparative Risk of bias: Critical | Calcium channel blockers (drug not specified) versus amiodarone | Amiodarone: 83% Calcium channel blockers: 50% | Amiodarone: 83% Calcium channel blockers: 50% | Not assessed |