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Table 1 Total vitamin C and DHA in plasma samples of critically ill patients receiving vitamin C therapy. Data from [32]

From: Measuring vitamin C in critically ill patients: clinical importance and practical difficulties—Is it time for a surrogate marker?

Bolus dosing regimen

T = 1

T = 2

2 g (n = 5)

10 g (n = 5)

2 g (n = 5)

10 g (n = 5)

Total vitamin C, μmol/l

174 [163.8–254.8]

1101 [1067.5–1287.6]

136.1 [97.2–203.3]

733.1 [703.2–879.6]

DHA, μmol/l

12.7 [7.5–25.6]

100.3 [61.9–113.2]

8.7 [3.3–24.8]

63.6 [31.2–69.5]

DHA, % of Tot (95% CI)

7.7 (2.8–12.7)

7.7 (4.1–11.2)

8.8 (0.8–16.8)

6.8 (3.6–10.0)

Continuous dosing regimen

T = 24

T = 48

2 g (n = 5)

10 g (n = 5)

2 g (n = 5)

10 g (n = 5)

Total vitamin C, μmol/l

101.4 [15.8–134.9]

428.3 [352.8–612]

108.2 [42.0–174.1]

453.5 [318.9–1230.8]

DHA, μmol/l

11.7 [1.5–18.3]

31.9 [15.2–48.7]

8.4 [4.2–18.9]

18.6 [9.1–50.3]

DHA, % of Tot (95% CI)

13.7 (5.3–22.0)

6.5 (3.1–9.9)

10.2 (2.5–17.9)

4.2 (0.1–8.3)

  1. Data are presented as median [IQR]
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Critical Care

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