Table 1 Clinical characteristics, respiratory parameters and outcomes of the study population
From: Static compliance and driving pressure are associated with ICU mortality in intubated COVID-19 ARDS
|  | Overall population n = 241 |
|---|---|
Clinical characteristics | |
Age (years) | 66 [58–73] |
Gender (male) | 189 (78%) |
SOFA score at ICU admission | 5 [4–8] |
BMI (kg/m2) | 27 [25–30] |
Charlson comorbidity index | 1 [1, 2] |
Onset of symptoms (days) | 7 [3–9] |
Hospital LOS before ICU (days) | 2 [1–5] |
Hospital LOS before CMV (days) | 2 [1–5] |
Gas exchange, at first day of CMV | |
pH | 7.41 [7.36–7.46] |
PaO2/FiO2 (mmHg) | 142 [102–216] |
PaCO2 (mmHg) | 44 [38–52] |
Ventilator settings and variables, at first day of CMV | |
Tidal volume (ml/kg of ideal body weight) | 7.8 [6.9–8.8] |
Set respiratory rates (breaths/min) | 16 [14–20] |
Total PEEP (cmH2O) | 12 [10–13] |
FiO2 (%) | 60 [50–70] |
Plateau pressure (cmH2O) | 23 [20–26] |
Driving pressure (cmH2O) | 11 [9–13] |
Static compliance of the respiratory system (ml/cmH2O) | 48 [39–60] |
Respiratory treatments before CMV | |
NIV failure | 110 (46%) |
HFOT failure | 27 (11%) |
None | 104 (43%) |
Adjunctive therapies during ICU stay | |
Prone position | 202 (84%) |
Neuromuscular blockers > 24 h | 212 (88%) |
V–V ECMO | 5 (2%) |
V–A ECMO | 1 (0.4%) |
Outcomes | |
ICU mortality | 71 (29%) |
60-day mortality | 78 (32%) |
Length of CMV (days) | 12 [7–16] |
ICU LOS (days) | 15 [9–25] |
Hospital LOS (days) | 30 [18–41] |