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Table 1 Clinical characteristics, respiratory parameters and outcomes of the study population

From: Static compliance and driving pressure are associated with ICU mortality in intubated COVID-19 ARDS

  Overall population
n = 241
Clinical characteristics
Age (years) 66 [58–73]
Gender (male) 189 (78%)
SOFA score at ICU admission 5 [4–8]
BMI (kg/m2) 27 [25–30]
Charlson comorbidity index 1 [1, 2]
Onset of symptoms (days) 7 [3–9]
Hospital LOS before ICU (days) 2 [1–5]
Hospital LOS before CMV (days) 2 [1–5]
Gas exchange, at first day of CMV
pH 7.41 [7.36–7.46]
PaO2/FiO2 (mmHg) 142 [102–216]
PaCO2 (mmHg) 44 [38–52]
Ventilator settings and variables, at first day of CMV
Tidal volume (ml/kg of ideal body weight) 7.8 [6.9–8.8]
Set respiratory rates (breaths/min) 16 [14–20]
Total PEEP (cmH2O) 12 [10–13]
FiO2 (%) 60 [50–70]
Plateau pressure (cmH2O) 23 [20–26]
Driving pressure (cmH2O) 11 [9–13]
Static compliance of the respiratory system (ml/cmH2O) 48 [39–60]
Respiratory treatments before CMV
NIV failure 110 (46%)
HFOT failure 27 (11%)
None 104 (43%)
Adjunctive therapies during ICU stay
Prone position 202 (84%)
Neuromuscular blockers > 24 h 212 (88%)
V–V ECMO 5 (2%)
V–A ECMO 1 (0.4%)
Outcomes
ICU mortality 71 (29%)
60-day mortality 78 (32%)
Length of CMV (days) 12 [7–16]
ICU LOS (days) 15 [9–25]
Hospital LOS (days) 30 [18–41]
  1. Data are expressed as median and interquartile range [IQR] or number (%)
  2. SOFA sequential organ failure assessment, ICU intensive care unit, BMI body mass index, LOS length of stay, CMV controlled mechanical ventilation, PaO2 partial pressure of arterial oxygen, PaO2/FiO2 ratio between partial pressure of arterial oxygen and fraction of inspired oxygen, PaCO2 partial pressure of carbon dioxide, PEEP positive end-expiratory pressure, FiO2 fraction of inspired oxygen, NIV non-invasive ventilation, HFOT high flow oxygen therapy, V–V veno–venous, V–A veno–arterial, ECMO extracorporeal membrane oxygenation