Table 2 Ventilatory parameters in matched patients with COVID-19 (n = 112) and non-COVID-19 pulmonary ARDS (n = 198) at days 1, 3 and 7
Day 1 | Day 3 | Day 7 | |||||||
|---|---|---|---|---|---|---|---|---|---|
COVID-19 | Non-COVID-19 | p value | COVID-19 | Non-COVID-19 | p value | COVID-19 | Non-COVID-19 | p value | |
Extubated, n | 0 (0) | 3 (2) | 0.556 | 5 (4) | 14 (7) | 0.463 | 27 (24) | 38 (19) | 0.313 |
On PSV, n | 11 (10) | 0 (0) | < 0.001 | 25 (22) | 5 (3) | < 0.001 | 31 (28) | 16 (9) | < 0.001 |
On ACV, n | 97 (87) | 186 (93) | 0.062 | 75 (68) | 162 (82) | 0.005 | 38 (34) | 119 (60) | < 0.001 |
On ECMO, n | 2 (2) | 0 (0) | 0.130 | 3 (3) | 0 (0) | 0.046 | 7 (6) | 0 (0) | < 0.001 |
Tidal volume, ml kg PBW−1 | 6.1 [5.9–6.8] | 6.0 [6.0–6.0] | 0.014 | 6.1 [5.9–6.9] | 6.0 [6.0–6.1] | 0.190 | 6.4 [5.9–7.4] | 6.0 [6.0–6.8] | 0.572 |
Respiratory rate, min−1 | 27 [24–30] | 30 [26–34] | < 0.001 | 28 [25–33] | 29 [24–33] | 0.884 | 31 [26–35] | 26 [20–32] | 0.007 |
Minute Ventilation, L min−1 | 10.9 [9.3–12.6] | 11.9 [9.8–13.0] | 0.059 | 11.5 [10.3–14.2] | 11.6 [10.0–13.2] | 0.553 | 12.3 [10.4–14.6] | 12.5 [10.4–14.0] | 0.954 |
PEEP set, cmH2O | 12 [10–14] | 12 [8–16] | 0.744 | 12 [9–14] | 10 [7–16] | 0.489 | 14 [10–15] | 7 [5–10] | < 0.001 |
Plateau pressure, cmH2O | 24 [21–28] | 27 [22–28] | 0.029 | 25 [21–28] | 26 [20–28] | 0.832 | 27 [23–28] | 23 [19–28] | 0.017 |
FiO2 | 0.5 [0.4–0.7] | 0.6 [0.5–0.8] | 0.021 | 0.5 [0.4–0.6] | 0.5 [0.3–0.7] | 0.426 | 0.5 [0.4–0.7] | 0.5 [0.4–0.6] | 0.649 |
pH | 7.39 [7.33–7.45] | 7.36 [7.30–7.41] | < 0.001 | 7.38 [7.33–7.43] | 7.40 [7.35–7.44] | 0.109 | 7.41 [7.34–7.43] | 7.43 [7.37–7.48] | 0.001 |
PaCO2, mmHg | 42 [36–46] | 43 [39–50] | 0.030 | 44 [40–49] | 42 [37–50] | 0.163 | 48 [41–55] | 42 [36–48] | < 0.001 |