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Fig. 6 | Critical Care

Fig. 6

From: The predicting roles of carcinoembryonic antigen and its underlying mechanism in the progression of coronavirus disease 2019

Fig. 6

The abnormal expressions of CRGs in COVID-19 patients were COVID-19-specific and not related to CEA involvement in ALI and IPF. Due to the close correlation between CEA and ALI and IPF, we initially speculated that the poor prognosis of COVID-19 patients mediated by CEA might be related to ALI and IPF pathophysiologically. To validate this hypothesis, scRNA-seq data of ALI and IPF mouse lungs were also downloaded to evaluated the distribution and expression of CRGs, key receptor–ligand pair of cellular communication and potential downstream pathways. The UAMP analysis identified 18 clusters and 6 cell types in ALI mouse lungs while there were no abnormal expressions of CRGs (A, C). And the interferon response and cell proliferation signaling pathways were not significantly activated in type II pneumocytes of ALI mouse lungs (D). Similarly, abnormal expressions of CRGs were also not detected in 31 clusters and 10 cell types of IPF mouse lungs (E, G). Besides, the heatmap of GSVA also showed that the interferon response and cell proliferation signaling pathways were not activated in type II pneumocytes of IPF mouse lungs (H)

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Critical Care

ISSN: 1364-8535