Evaluation of thiamine as adjunctive therapy in COVID-19 critically ill patients: a two-center propensity score matched study

Table 2 Regression analysis for ICU complication(s) during ICU stay

Outcomes	Before propensity score					After propensity score
Outcomes	Control (650 patients)	Thiamine (88 patients)	P value	Odds ratio (OR) (95%CI)	P value	Control (83 patients)	Thiamine (83 patients)	P valve	Odds ratio (OR) (95%CI)	P value
Acute kidney injury (AKI), n (%)#	304/639 (47.6)	31/87 (35.6)	0.04^^	0.56 (0.36,0.86)	0.009^{*^}	21/82 (43.9)	15/83 (33.7)	0.26^^	0.91 (0.49,1.68)	0.75^$
Liver injury, n (%)#	70/637(10.9)	7/87 (8.1)	0.40^^	0.09 (0.04,0.19)	< .0001^{*^}	5/82 (6.1)	6/83 (7.2)	0.77^^	0.93 (0.30,2.87)	0.90^$
Respiratory failure required MV, n (%)$*	67/197 (34.0)	16/42 (38)	0.61^^	1.05 (0.49, 2.22)	0.90*^	14/31 (45.1)	16/40 (40)	0.66^^	0.95 (0.35, 2.57)	0.92^$
Thrombosis/infarction during ICU, n(%)#	71/632 (11.2)	2/87 (2.3)	0.01^^	0.03 (0.008,0.10)	< .0001^{*^}	9/81 (11.1)	2/83 (2.4)	0.02^^	0.19 (0.04,0.88)	0.03^$

^#Denominator of the percentage is the total number of patients
^$*Denominator of the percentage is non-mechanically ventilated patients with 24 h of ICU admission
^^Chi-square test is used to calculate the P value
^$Propensity score adjusted logistic regression is used to calculate odds ratio and P value
*^Multivariable logistic regression is used after adjusting for patient’s baseline severity scores, systemic use of corticosteroids and hospital center to calculate odds ratio and P value

ISSN: 1364-8535