Table 1 Clinical characteristics and outcome of the entire cohort according to EOLIA criteria
Characteristics, outcomes and complications | ARDS patients without EOLIA criteria (n = 685) | ARDS patients with EOLIA criteria (n = 67) | p-value |
|---|---|---|---|
Age (years) | 59 (47–72) | 56 (47–70) | 0.43 |
Male sex, n (%) | 465 (68) | 42 (63) | 0.47 |
SAPS II | 51 (38–65) | 47 (33–64) | 0.27 |
Weight (kg) | 77 (65–84) | 70 (59–86) | 0.43 |
Cause of ARDS, n (%) | 0.20 | ||
Pneumonia | 83 (12) | 8 (12) | |
Aspiration | 259 (39) | 34 (51)) | |
Non-pulmonary sepsis | 245 (37) | 17 (26) | |
Other causes | 83 (12) | 7 (11) | |
Respiratory setting at inclusion | |||
Tidal volume (ml/kg) | 6.7 (6.0–8.0) | 6.02 (5.4–6.9) | < 0.01 |
Respiratory rate (cycle/min) | 22 (16–27) | 26 (22–30) | < 0.01 |
PEEP (cmH2O) | 8 (5–10) | 10 (7–12) | < 0.01 |
Plateau pressure (cmH2O) | 24 (21–28) | 27 (25–29) | < 0.01 |
Compliance (ml/cmH2O) | 30.7 (24–39.1) | 25.9 (19.3–33.8) | < 0.01 |
Driving pressure (cmH2O) | 15 (13–19) | 17 (14–19.8) | 0.04 |
Arterial blood gases | |||
PaO2/FiO2 ratio (mmHg) | 114 (90–120) | 62 (55–72) | < 0.01 |
PaCO2 (mmHg) | 44 (38–52) | 48 (41–60) | < 0.01 |
Shock, n (%) | 449 (66) | 53 (79) | 0.04 |
Prone positioning, n (%) | 163 (24) | 55 (82) | < 0.01 |
VV ECMO in rescue during ARDS course, n (%) | 0 (0) | 8 (12) | < 0.01 |
RRT during ARDS course, n (%) | 126 (30) | 15 (40) | 0.27 |
Echocardiographic findings | |||
RVEDA/LVEDA | 0.68 (0.57–0.81) | 0.83 (0.64–1.04) | < 0.01 |
Systolic pulmonary artery pressure (mmHg) | 35 (20–48) | 52 (35–59) | < 0.01 |
Severe acute cor pulmonale | 43 (6) | 11 (16) | < 0.01 |
Outcome, n (%) | |||
ICU mortality | 243 (36) | 31 (46) | 0.10 |
ICU stay (days) | 16 (8–30) | 15 (6–31) | 0.43 |