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Table 1 Sample characteristics

From: Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study

Variable Overall CFS = 1 CFS = 2 CFS = 3 CFS = 4 CFS = 5 CFS = 6 CFS = 7 CFS = 8 CFS = 9
n 7487 319 756 1723 1446 1097 1127 730 246 43
Male sex (n, %) 3934 (52.5) 200 (62.7) 455 (60.2) 988 (57.3) 783 (54.1) 530 (48.3) 504 (44.7) 333 (45.6) 122 (49.6) 19 (44.2)
Age, years (median [IQR]) 84.0 [81.0, 87.0] 82.0 [81.0, 85.0] 83.0 [81.0, 86.0] 83.0 [81.0, 86.0] 84.0 [81.0, 86.0] 84.0 [82.0, 87.0] 84.0 [82.0, 88.0] 85.0 [82.0, 88.0] 84.0 [82.0, 87.0] 83.0 [81.0, 87.0]
SOFA score (median [IQR]) 7.0 [4.0, 10.0] 6.0 [3.0, 8.0] 6.0 [4.0, 10.0] 6.0 [4.0, 10.0] 6.0 [4.0, 10.0] 7.0 [4.0, 10.0] 7.0 [4.0, 10.0] 8.0 [5.0, 10.0] 9.0 [6.0, 12.0] 9.0 [7.5, 12.5]
Reason for admission (n, %)
 Respiratory failure 1809 (24.2) 67 (21.0) 154 (20.4) 358 (20.8) 374 (25.9) 278 (25.3) 300 (26.6) 191 (26.2) 73 (29.7) 14 (32.6)
 Circulatory failure 1057 (14.1) 32 (10.0) 111 (14.7) 240 (13.9) 221 (15.3) 157 (14.3) 166 (14.7) 100 (13.7) 23 (9.3) 7 (16.3)
 Combined respiratory/circulatory failure 874 (11.7) 17 (5.3) 58 (7.7) 165 (9.6) 183 (12.7) 137 (12.5) 141 (12.5) 116 (15.9) 50 (20.3) 7 (16.3)
 Sepsis 992 (13.2) 26 (8.2) 80 (10.6) 242 (14.0) 159 (11.0) 162 (14.8) 152 (13.5) 119 (16.3) 45 (18.3) 7 (16.3)
 Emergency surgery 900 (12.0) 49 (15.4) 96 (12.7) 246 (14.3) 166 (11.5) 131 (11.9) 137 (12.2) 60 (8.2) 14 (5.7) 1 (2.3)
 Non-traumatic cerebral pathology 477 (6.4) 38 (11.9) 67 (8.9) 104 (6.0) 84 (5.8) 52 (4.7) 68 (6.0) 48 (6.6) 12 (4.9) 4 (9.3)
 Multiple trauma without head injury 141 (1.9) 12 (3.8) 28 (3.7) 39 (2.3) 25 (1.7) 14 (1.3) 18 (1.6) 5 (0.7) 0 (0.0) 0 (0.0)
 Multiple trauma with head injury 128 (1.7) 15 (4.7) 24 (3.2) 36 (2.1) 18 (1.2) 18 (1.6) 9 (0.8) 7 (1.0) 1 (0.4) 0 (0.0)
 Isolated head injury 180 (2.4) 10 (3.1) 29 (3.8) 43 (2.5) 30 (2.1) 20 (1.8) 29 (2.6) 13 (1.8) 4 (1.6) 2 (4.7)
 Other 929 (12.4) 53 (16.6) 109 (14.4) 250 (14.5) 186 (12.9) 128 (11.7) 107 (9.5) 71 (9.7) 24 (9.8) 1 (2.3)
NIV (n, %) 1854 (24.8) 71 (22.3) 155 (20.5) 383 (22.2) 375 (25.9) 298 (27.2) 306 (27.2) 200 (27.4) 53 (21.5) 13 (30.2)
Intubation (n, %) 3804 (50.8) 165 (51.7) 421 (55.7) 885 (51.4) 731 (50.6) 510 (46.5) 551 (48.9) 357 (48.9) 159 (64.6) 25 (58.1)
Vasoactive drugs (n, %) 4400 (58.8) 173 (54.2) 436 (57.7) 1004 (58.3) 837 (57.9) 646 (58.9) 677 (60.1) 436 (59.7) 162 (65.9) 29 (67.4)
Renal replacement therapy (n, %) 820 (11.0) 24 (7.5) 72 (9.5) 208 (12.1) 165 (11.4) 101 (9.2) 126 (11.2) 76 (10.4) 43 (17.5) 5 (11.6)
Life sustaining treatment limitation
 None 4930 (65.8) 239 (74.9) 571 (75.5) 1236 (71.7) 982 (67.9) 688 (62.7) 669 (59.4) 370 (50.7) 154 (62.6) 21 (48.8)
 Withdrawal 1108 (14.8) 39 (12.2) 107 (14.2) 234 (13.6) 194 (13.4) 166 (15.1) 183 (16.2) 135 (18.5) 39 (15.9) 11 (25.6)
 Withholding 1449 (19.4) 41 (12.9) 78 (10.3) 253 (14.7) 270 (18.7) 243 (22.2) 275 (24.4) 225 (30.8) 53 (21.5) 11 (25.6)
Length of stay in the ICU, days, non-survivors (median [IQR]) 3.00 [1.00, 7.93] 5.10 [1.87, 0.82] 3.00 [0.67, 8.85] 3.30 [1.00, 8.00] 3.80 [1.10, 9.00] 2.50 [1.00, 7.20] 3.00 [1.00, 7.00] 2.20 [0.80, 6.05] 3.00 [1.00, 8.20] 2.30 [0.80, 5.47]
Length of stay in the ICU, days, survivors (median [IQR]) 3.30 [1.70, 7.00] 3.80 [1.80, 8.00] 3.50 [1.80, 6.93] 3.60 [1.80, 7.82] 3.50 [1.70, 7.00] 3.15 [1.50, 6.53] 3.00 [1.60, 6.23] 3.00 [1.35, 6.25] 6.20 [2.00,15.00] 3.70 [1.00,12.50]
Death in the ICU (n, %) 2024 (27.0) 60 (18.8) 188 (24.9) 403 (23.4) 369 (25.5) 273 (24.9) 331 (29.4) 259 (35.5) 113 (45.9) 28 (65.1)
Death in 30-day follow-up (n, %) 2985 (39.9) 91 (28.5) 254 (33.6) 576 (33.4) 545 (37.7) 416 (37.9) 513 (45.5) 406 (55.6) 149 (60.6) 35 (81.4)
  1. IQR interquartile range, ICU intensive care unit, NIV non-invasive ventilation, SOFA Sequential Organ Failure Assessment