Table 1 Clinical characteristics at admission and at weaning trial in patients that succeeded and failed CPAP weaning
From: Predictors of weaning from helmet CPAP in patients with COVID-19 pneumonia
Characteristics | Weaning success (n = 61) | Weaning failure (n = 13) | p valuea |
|---|---|---|---|
Age, years | 62 (12) | 74 (8) | 0.001 |
Males, n (%) | 43 (70) | 8 (61) | 0.526 |
Hypertension, n (%) | 30 (49) | 7 (54) | 0.760 |
Diabetes mellitus, n (%) | 13 (21) | 3 (23) | 0.999 |
Ischemic heart disease, n (%) | 6 (10) | 4 (31) | 0.067 |
Obesity, n (%) | 26 (43) | 6 (46) | 0.816 |
Respiratory disease, n (%) | 10 (16) | 0 (0) | 0.116 |
CPAP days at weaning trial | 4 (2–6) | 4 (2.5–5) | 0.854 |
In-Hospital treatments | |||
Antibiotics, n (%) | 50 (82.0%) | 9 (69.2%) | 0.446 |
LMWH prophylactic, n (%) | 39 (63.9%) | 8 (61.5%) | 0.999 |
LMWH therapeutic, n (%) | 30 (49.2%) | 9 (69.2%) | 0.189 |
Systemic corticosteroids, n (%) | 46 (75.4%) | 9 (69.2%) | 0.729 |
Clinical status at admission | |||
Lymphocytes, × 106/L | 900 (600–1400) | 800 (700–1000) | 0.931 |
D-Dimer, µg/L FEU | 888 (572–2101) | 1056 (544–1632) | 0.922 |
CRP, mg/L | 85 (42–127) | 110 (85–215) | 0.060 |
Creatinine, mg/dL | 0.8 (0.7–1.0) | 0.9 (0.8–1.6) | 0.091 |
BUN, mg/dL | 38 (28–53) | 52 (34–70) | 0.093 |
Glasgow coma scale | 15 (15–15) | 15 (14.5–15) | 0.067 |
SOFA | 2 (2–3) | 3 (2–4.5) | 0.204 |
Respiratory rate, bpm | 24 (22–29) | 26 (24–33) | 0.275 |
PaO2/FiO2, mmHg | 194 (122–273) | 140 (86.7–281.0) | 0.604 |
A-a O2 gradient, mmHg | 204 (69–325) | 242 (66–336) | 0.960 |
pH | 7.48 (0.05) | 7.49 (0.05) | 0.389 |
PaCO2, mmHg | 36 (7) | 35 (9) | 0.598 |
ROX index | 7.6 (4.8–14.5) | 8.1 (4.3–16.3) | 0.889 |
Clinical status the day of weaning trial | |||
D-Dimer, µg/L FEU | 899 (545–1425) | 1244 (845–1375) | 0.183 |
CRP, mg/L | 36 (9–59) | 70 (18–115) | 0.085 |
SOFA | 2 (1.5 – 3) | 3 (3–4) | 0.003 |
GCS | 15 (15–15) | 15 (15–15) | 0.423 |
A-a O2 gradient, mmHg | 208 (151–269) | 245 (206–445) | 0.010 |
PaO2/FiO2, mmHg | 243 (98) | 171 (56) | 0.014 |
Respiratory rate, bpm | 20 (18–22) | 24 (22–27) | < 0.001 |
pH | 7.45 (7.42–7.47) | 7.44 (7.42–7.48) | 0.638 |
PaCO2, mmHg | 42 (6) | 41 (6) | 0.653 |
ROX index | 9 (8–11) | 7.4 (4.1–8.5) | 0.002 |
mROX index, mmHg/bpm | 11.9 (8.5–14.3) | 6.6 (5.6–8.8) | < 0.001 |