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Table 3 Comparison of MDW with WBC, PCT and CRP performance for sepsis detection Cutoff: WBC < 4,000/mm3 or WBC > 12,000/mm3, MDW > 21.5, PCT > 0.25 µg/L, CRP > 22 mg/L)

From: Monocyte distribution width (MDW) performance as an early sepsis indicator in the emergency department: comparison with CRP and procalcitonin in a multicenter international European prospective study

Sepsis-2

Parameter

Sensitivity [95%CI]

Specificity [95%CI]

PPV [95%CI]

NPV [95%CI]

LR + [95%CI]

LR − [95%CI]

AUC [95%CI]

MDW

0.75 [0.69–0.80]

0.73 [0.70–0.75]

0.36 [0.32–0.40]

0.93 [0.92–0.95]

2.76 [2.46–3.09]

0.34 [0.28–0.43]

0.81 [0.78–0.84]

WBC

0.69 [0.63–0.74]

0.83 [0.81–0.85]

0.45 [0.40–0.50]

0.93 [0.91–0.94]

4.00 [3.50–4.60]

0.40 [0.30–0.50]

0.76 [0.72–0.79]

PCT

0.45 [0.39–0.51]

0.88 [0.86–0.90]

0.44 [0.38–0.50]

0.89 [0.87–0.90]

3.80 [3.10–4.65-]

0.62 [0.56–0.70]

0.78 [0.75–0.81]

CRP

0.85 [0.80–0.88]

0.72 [0.70–0.75]

0.39 [0.35–0.43]

0.96 [0.94–0.97]

3.06 [2.76–3.39]

0.21 [0.16–0.28]

0.85 [0.83–0.87]

MDW + WBC

      

0.86 [0.84–0.88]

MDW + PCT

      

0.81 [0.78–0.84]

MDW + CRP

      

0.85 [0.82–0.87]

MDW + WBC + PCT

      

0.86 [0.84–0.89]

MDW + WBC + CRP

      

0.87 [0.85–0.89]

Sepsis-3

       

MDW

0.81 [0.73–0.86]

0.69 [0.67–0.72]

0.22 [0.18–0.25]

0.97 [0.96–0.98]

2.63 [2.35–2.94]

0.28 [0.20–0.39]

0.82 [0.79–0.85]

WBC

0.49 [0.41–0.57]

0.77 [0.74–0.79]

0.18 [0.15–0.22]

0.94 [0.92–0.95]

2.10 [1.70–2.50]

0.70 [0.60–0.80]

0.65 [0.60–0.70]

PCT

0.60 [0.52–0.68]

0.87 [0.85–0.89]

0.33 [0.27–0.39]

0.95 [0.94–0.96]

4.63 [3.83–5.60]

0.46 [0.37–0.56]

0.84 [0.80–0.87]

CRP

0.89 [0.83–0.93]

0.68 [0.66–0.71]

0.23 [0.19–0.26]

0.98 [0.97–0.99]

2.79 [2.53–3.07]

0.16 [0.10–0.26]

0.85 [0.82–0.87]

MDW + WBC

      

0.83 [0.79–0.86]

MDW + PCT

      

0.82 [0.79–0.86]

MDW + CRP

      

0.85 [0.82–0.88]

MDW + WBC + PCT

      

0.83 [0.80–0.86]

MDW + WBC + CRP

      

0.85 [0.82–0.87]

  1. MDW, monocyte distribution width; WBC, white blood count; PCT, procalcitonin; CRP, C-reactive protein; PPV, positive predictive value; NPV, negative predictive value; LR + : positive likelihood ratio. LR-, negative likelihood ratio; AUC: area under the ROC curve; CI confidence interval