Monocyte distribution width (MDW) performance as an early sepsis indicator in the emergency department: comparison with CRP and procalcitonin in a multicenter international European prospective study

Table 2 Added value of MDW to SIRS criteria for Sepsis-2 diagnosis (pretest = 0.17), and to qSOFA for Sepsis-3 diagnosis (pretest = 0.9)

Sepsis 2 & SIRS	No SIRS	1 SIRS	2 SIRS	3 SIRS	4 SIRS	Total
Total patients	515	594	271	117	20	1517
Sepsis patients (#)	4	21	141	81	13	260
Sepsis probability, MDW unknown	0.8%	3.5%	51.8%	69.0%	64.8%	17.0%
Sepsis probability, MDW normal	0.3%	1.7%	31.1%	37.6%	28.4%	6.6%
Sepsis probability, MDW abnormal	2.4%	7.8%	71.2%	83.6%	84.5%	36.1%
Sepsis odds (MDW abnormal/normal) [95% CI]	9.3	4.7	2.3	2.2	3.0	5.5[4.2–7.1]

Sepsis 3 & qSOFA	No qSOFA	1 qSOFA	2 qSOFA	3 qSOFA	Total
Total patients	1136	347	33	1	1517
Sepsis patients (#)	53	72	18	1	144
Sepsis probability, MDW unknown	4.4%	19.8%	53.1%		9.0%
Sepsis probability, MDW normal	1.2%	8.1%	28.8%		2.7%
Sepsis probability, MDW abnormal	12.0%	31.9%	63.9%		20.6%
Sepsis odds (MDW abnormal/normal) [95% CI]	10.1	3.9	2.2		7.6 [5.1–11.3]

MDW, monocyte distribution width; SIRS, systemic inflammatory response syndrome; qSOFA, quick Sequential Organ Failure Assessment; CI, Confidence Interval

ISSN: 1364-8535