No reintubation (n = 71) | Reintubation (n = 75) | P value | |
---|---|---|---|
Characteristics of the patients at admission | |||
Age, years | 72 ± 9 | 69 ± 9 | 0.049 |
Male sex, n (%) | 40 (56%) | 53 (71%) | 0.07 |
Body-mass index, kg/m2 | 30 ± 8 | 27 ± 6 | 0.02 |
Obesity, n (%) | 30 (43%) | 20 (27%) | 0.04 |
SAPS II at admission, points | 58 ± 18 | 57 ± 18 | 0.86 |
Underlying chronic cardiac disease, n (%) | 33 (46%) | 32 (43%) | 0.64 |
Underlying chronic lung disease, n (%) | 29 (41%) | 28 (37%) | 0.66 |
Acute respiratory failure as reason for intubation, n (%) | 43 (61%) | 46 (61%) | 0.92 |
Characteristics of the patients the day of extubation | |||
SOFA score, points | 4.1 ± 2.8 | 4.8 ± 2.7 | 0.11 |
Duration of mechanical ventilation, median (IQR), days | 6 [3–13] | 6 [3–13] | 0.85 |
Weaning difficulty, n (%) | 0.20 | ||
Simple weaning | 36 (51%) | 49 (65%) | |
Difficult or prolonged weaning | 35 (49%) | 26 (35%) | |
Ineffective cough, n/n total (%) | 25/67 (37%) | 21/73 (29%) | 0.28 |
Abundant secretions, n/n total (%) | 24/68 (35%) | 38/72 (53%) | 0.04 |
Administration of steroids before extubation, n (%) | 12 (17%) | 5 (7%) | 0.05 |
Prophylactic NIV after extubation, n (%) | 32 (45%) | 31 (41%) | 0.65 |
Characteristics at time of ARF | |||
Interval between extubation and respiratory failure, hours | 20 [5–47] | 22 [4–57] | 0.89 |
Systolic arterial pressure, mm Hg | 135 ± 25 | 136 ± 24 | 0.67 |
Diastolic arterial pressure, mm Hg | 66 ± 14 | 67 ± 15 | 0.94 |
Heart rate, beats/min | 82 ± 33 | 95 ± 30 | 0.01 |
Respiratory rate, breaths/min | 39 ± 25 | 35 ± 22 | 0.38 |
Clinical signs suggesting respiratory distress, n (%) | 38 (54%) | 15 (20%) | < 0.001 |
SpO2, % | 95 ± 4 | 94 ± 7 | 0.47 |
PaO2, mm Hg | 83 ± 26 | 80 ± 36 | 0.59 |
PaO2/FiO2, mm Hg | 196 ± 76 | 175 ± 72 | 0.18 |
pH, units | 7,42 ± 0,08 | 7,44 ± 0,09 | 0.38 |
PaCO2, mm Hg | 47 ± 13 | 43 ± 15 | 0.09 |
Hypercapnia (PaCO2 > 45 mm Hg), n/n total (%) | 29/62 (47%) | 17/61 (28%) | 0.03 |
Treatment of respiratory failure | |||
Use of curative non-invasive ventilation, n (%) | 44 (61%) | 40 (53%) | 0.29 |
Duration of administered treatment, hours | 57 [28–86] | 5 [2–16] | < 0.001 |
Duration of curative high-flow nasal oxygen hours | 38 [16–72] | 3 [1–10] | < 0.001 |
Duration of curative NIV, hours | 10 [0–27] | 2 [0–7] | 0.002 |