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Table 3 Hazard ratio for (A) continuous CCL14 and (B) CCL14 tertiles, unadjusted and adjusted for baseline serum creatinine and non-renal APACHE III score in a Cox regression model with CCL14 as a time-dependent covariate

From: External validation of urinary C–C motif chemokine ligand 14 (CCL14) for prediction of persistent acute kidney injury

Model

HR (95% CI)

P value

A. Urinary CCL14 concentration as a continuous variable in model

Unadjusted (CCL14 only)

1.67 (1.36–2.06)

< 0.001

Adjusted for baseline serum creatinine

1.55 (1.24–1.93)

< 0.001

Adjusted for baseline non-renal APACHE

1.51 (1.22–1.88)

< 0.001

Adjusted for baseline serum creatinine and non-renal APACHE

1.41 (1.13–1.75)

0.003

Model

Tertile 2 versus 1

Tertile 3 versus 1

HR (95% CI)

P value

HR (95% CI)

P value

B. Urinary CCL14 concentration divided into tertiles and used as a categorical variable in model

Unadjusted (CCL14 only)

1.14 (0.61–2.13)

0.671

2.56 (1.46–4.50)

0.001

Adjusted for baseline serum creatinine

1.09 (0.58–2.02)

0.795

2.16 (1.20–3.88)

0.010

Adjusted for baseline non-renal APACHE

1.15 (0.62–2.14)

0.662

2.10 (1.18–3.75)

0.012

Adjusted for baseline serum creatinine and non-renal APACHE

1.15 (0.62–2.15)

0.651

1.83 (1.02–3.29)

0.043

  1. Model is for time to RRT and/or death within 90 days