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Table 2 Integrated discrimination improvement (IDI), category-free net reclassification improvement (cfNCI), and AUC difference with the addition of CCL14 to a reference clinical model with baseline serum creatinine and non-renal APACHE III score

From: External validation of urinary C–C motif chemokine ligand 14 (CCL14) for prediction of persistent acute kidney injury

 

Value

95% CI

P value

IDI

0.065

0.005–0.172

< 0.001

IDI: event

0.048

0.003–0.141

< 0.001

IDI: non-event

0.017

0.002–0.035

< 0.001

cfNRI

0.864

0.389–1.276

< 0.001

cfNRI: event

0.322

0.051–0.633

0.004

cfNRI: non-event

0.542

0.272–0.713

< 0.001

AUC ref model

0.768

0.662–0.872

< 0.001

AUC new model

0.834

0.738–0.918

< 0.001

AUC difference

0.065

0.007–0.143

< 0.001

Model

Variable

OR

95% CI

P value

Reference

Non-renal APACHE

1.85

1.25–2.73

0.002

 

Baseline serum creatinine

2.26

1.42–3.62

  0.001

New

Non-renal APACHE

1.63

1.12–2.39

0.012

 

Baseline serum creatinine

2.09

1.24–3.50

0.005

 

CCL14

1.63

1.21–2.19

0.001

  1. Event is persistent severe AKI. Odds ratio (OR), 95% confidence interval (CI), and P value for each variable in the models are shown in the lower table
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Critical Care

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