Skip to main content

Table 2 Integrated discrimination improvement (IDI), category-free net reclassification improvement (cfNCI), and AUC difference with the addition of CCL14 to a reference clinical model with baseline serum creatinine and non-renal APACHE III score

From: External validation of urinary C–C motif chemokine ligand 14 (CCL14) for prediction of persistent acute kidney injury

  Value 95% CI P value
IDI 0.065 0.005–0.172 < 0.001
IDI: event 0.048 0.003–0.141 < 0.001
IDI: non-event 0.017 0.002–0.035 < 0.001
cfNRI 0.864 0.389–1.276 < 0.001
cfNRI: event 0.322 0.051–0.633 0.004
cfNRI: non-event 0.542 0.272–0.713 < 0.001
AUC ref model 0.768 0.662–0.872 < 0.001
AUC new model 0.834 0.738–0.918 < 0.001
AUC difference 0.065 0.007–0.143 < 0.001
Model Variable OR 95% CI P value
Reference Non-renal APACHE 1.85 1.25–2.73 0.002
  Baseline serum creatinine 2.26 1.42–3.62   0.001
New Non-renal APACHE 1.63 1.12–2.39 0.012
  Baseline serum creatinine 2.09 1.24–3.50 0.005
  CCL14 1.63 1.21–2.19 0.001
  1. Event is persistent severe AKI. Odds ratio (OR), 95% confidence interval (CI), and P value for each variable in the models are shown in the lower table