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Table 3 Cox and competing risks regressions for time to invasive mechanical ventilation according to the presence of hypouricemia

From: Serum uric acid, disease severity and outcomes in COVID-19

 

Univariate

Multivariate—model 1

Multivariate—model 2

 

HR

95% CI

P

Adj. HR

95% CI

P

Adj. HR

95% CI

P

Cox (mechanical ventilation or death)

No hypouricemia

1.0 (ref.)

1.0 (ref.)

1.0 (ref.)

Hypouricemia (discovery)

3.9

2.3–6.7

 < 0.001

6.6

3.6–12.1

 < 0.001

3.1

1.6–6.1

0.001

Hypouricemia (validation)

6.7

4.1–11.1

 < 0.001

6.2

3.6–10.7

 < 0.001

5.9

3.4–10.3

 < 0.001

Hypouricemia (pooled)

5.1

3.6–7.4

 < 0.001

6.0

4.1–8.8

 < 0.001

5.6

3.8–8.3

 < 0.001

 

Univariate

Multivariate—model 1

Multivariate—model 2

 

sHR

95% CI

P

Adj. sHR

95% CI

P

Adj. sHR

95% CI

P

Competing risks (mechanical ventilation)

No hypouricemia

1.0 (ref.)

1.0 (ref.)

1.0 (ref.)

Hypouricemia (discovery)

11.1

5.2–23.7

 < 0.001

17.9

7.3–43.7

 < 0.001

7.8

3.1–20.0

 < 0.001

Hypouricemia (validation)

41.6

12.6–137.5

 < 0.001

40.2

12.0–134.9

 < 0.001

36.4

10.6–124.9

 < 0.001

Hypouricemia (pooled)

18.1

9.7–33.8

 < 0.001

20.8

10.4–41.4

 < 0.001

18.8

9.3–38.1

 < 0.001

  1. Univariate and multivariate Cox regression analyses predicting mechanical ventilation or death and competing risk regression analyses predicting need for mechanical ventilation taking into account the competing risks of death or discharge. Model 1 is adjusted for age, gender and baseline biological parameters (CRP, LDH, lymphocytes). Model 2 is adjusted for the same parameters and severity biological parameters (higher CRP and LDH levels) during hospitalization
  2. HR, hazard ratio; sHR, subdistribution HR; adj., adjusted; 95% CI, 95% confidence interval