From: Serum uric acid, disease severity and outcomes in COVID-19
Univariate | Multivariate—model 1 | Multivariate—model 2 | |||||||
---|---|---|---|---|---|---|---|---|---|
HR | 95% CI | P | Adj. HR | 95% CI | P | Adj. HR | 95% CI | P | |
Cox (mechanical ventilation or death) | |||||||||
No hypouricemia | 1.0 (ref.) | – | – | 1.0 (ref.) | – | – | 1.0 (ref.) | – | – |
Hypouricemia (discovery) | 3.9 | 2.3–6.7 | < 0.001 | 6.6 | 3.6–12.1 | < 0.001 | 3.1 | 1.6–6.1 | 0.001 |
Hypouricemia (validation) | 6.7 | 4.1–11.1 | < 0.001 | 6.2 | 3.6–10.7 | < 0.001 | 5.9 | 3.4–10.3 | < 0.001 |
Hypouricemia (pooled) | 5.1 | 3.6–7.4 | < 0.001 | 6.0 | 4.1–8.8 | < 0.001 | 5.6 | 3.8–8.3 | < 0.001 |
Univariate | Multivariate—model 1 | Multivariate—model 2 | |||||||
---|---|---|---|---|---|---|---|---|---|
sHR | 95% CI | P | Adj. sHR | 95% CI | P | Adj. sHR | 95% CI | P | |
Competing risks (mechanical ventilation) | |||||||||
No hypouricemia | 1.0 (ref.) | – | – | 1.0 (ref.) | – | – | 1.0 (ref.) | – | – |
Hypouricemia (discovery) | 11.1 | 5.2–23.7 | < 0.001 | 17.9 | 7.3–43.7 | < 0.001 | 7.8 | 3.1–20.0 | < 0.001 |
Hypouricemia (validation) | 41.6 | 12.6–137.5 | < 0.001 | 40.2 | 12.0–134.9 | < 0.001 | 36.4 | 10.6–124.9 | < 0.001 |
Hypouricemia (pooled) | 18.1 | 9.7–33.8 | < 0.001 | 20.8 | 10.4–41.4 | < 0.001 | 18.8 | 9.3–38.1 | < 0.001 |