Lung distribution of gas and blood volume in critically ill COVID-19 patients: a quantitative dual-energy computed tomography study

Table 3 Correlations between clinical and dual-energy computed tomography parameters

Dual-energy computed tomography parameters	D-dimer C-reactive protein				Respiratory system compliance^§		PaO₂/FiO₂		PaCO₂		Ventilatory Ratio^§
Dual-energy computed tomography parameters	ρ	p	ρ	p	ρ	p	ρ	p	ρ	p	ρ	p
Normally aerated lung tissue (%)	− 0.403	0.016*	− 0.488	0.003*	0.284	0.189	0.730	< 0.001*	0.483	0.003*	− 0.351	0.101
Poorly aerated lung tissue (%)	0.343	0.044*	0.236	0.172	− 0.144	0.511	− 0.342	0.044*	− 0.221	0.201	0.407	0.054
Non-aerated lung tissue (%)	0.379	0.025*	0.575	< 0.001*	− 0.280	0.196	− 0.637	< 0.001*	− 0.383	0.023*	0.108	0.625
Non-perfused lung tissue (%)	0.418	0.012*	0.061	0.730	− 0.071	0.747	− 0.12	0.491	0.385	0.023*	0.432	0.040*
Shunt lung tissue (%)	0.186	0.285	0.486	0.003*	− 0.105	0.634	− 0.579	< 0.001*	0.261	0.130	− 0.149	0.497
Lung tissue with gas:blood volume ratio < 1 (%)	− 0.418	0.012*	− 0.557	0.001*	0.422	0.045*	0.481	0.003*	− 0.441	0.008*	0.067	0.761
Lung tissue with gas:blood volume ratio > 1 (%)	− 0.285	0.097	− 0.169	0.333	− 0.166	0.449	0.471	0.004*	− 0.227	0.190	− 0.116	0.599
Dead-space lung tissue (%)	0.101	0.565	− 0.351	0.039*	0.165	0.451	0.289	0.092	0.070	0.690	0.205	0.349
Non-aerated, non-perfused lung tissue (%)	0.513	0.002*	0.531	0.001*	− 0.212	0.332	− 0.439	0.008*	0.497	0.002*	0.368	0.084
Lung tissue with gas:blood volume mismatch (%)	0.440	0.008*	0.481	0.003*	− 0.138	0.529	− 0.633	< 0.001*	0.440	0.008*	0.163	0.457

Gas:blood volume mismatch is the percent of lung mass accounted for by shunt, dead-space, and non-aerated, non-perfused regions. FiO₂: fraction of inspired oxygen; PaO₂: arterial oxygen partial pressure; PaCO₂: arterial carbon dioxide partial pressure
^*Significant correlation, p < 0.05
^§Correlations computed only in intubated patients (N = 23)

ISSN: 1364-8535