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Table 3 Correlations between clinical and dual-energy computed tomography parameters

From: Lung distribution of gas and blood volume in critically ill COVID-19 patients: a quantitative dual-energy computed tomography study

Dual-energy computed tomography parameters D-dimer
C-reactive protein
Respiratory system compliance§ PaO2/FiO2 PaCO2 Ventilatory Ratio§
ρ p ρ p ρ p ρ p ρ p ρ p
Normally aerated lung tissue (%) − 0.403 0.016* − 0.488 0.003* 0.284 0.189 0.730 < 0.001* 0.483 0.003* − 0.351 0.101
Poorly aerated lung tissue (%) 0.343 0.044* 0.236 0.172 − 0.144 0.511 − 0.342 0.044* − 0.221 0.201 0.407 0.054
Non-aerated lung tissue (%) 0.379 0.025* 0.575 < 0.001* − 0.280 0.196 − 0.637 < 0.001* − 0.383 0.023* 0.108 0.625
Non-perfused lung tissue (%) 0.418 0.012* 0.061 0.730 − 0.071 0.747 − 0.12 0.491 0.385 0.023* 0.432 0.040*
Shunt lung tissue (%) 0.186 0.285 0.486 0.003* − 0.105 0.634 − 0.579 < 0.001* 0.261 0.130 − 0.149 0.497
Lung tissue with gas:blood volume ratio < 1 (%) − 0.418 0.012* − 0.557 0.001* 0.422 0.045* 0.481 0.003* − 0.441 0.008* 0.067 0.761
Lung tissue with gas:blood volume ratio > 1 (%) − 0.285 0.097 − 0.169 0.333 − 0.166 0.449 0.471 0.004* − 0.227 0.190 − 0.116 0.599
Dead-space lung tissue (%) 0.101 0.565 − 0.351 0.039* 0.165 0.451 0.289 0.092 0.070 0.690 0.205 0.349
Non-aerated, non-perfused lung tissue (%) 0.513 0.002* 0.531 0.001* − 0.212 0.332 − 0.439 0.008* 0.497 0.002* 0.368 0.084
Lung tissue with gas:blood volume mismatch (%) 0.440 0.008* 0.481 0.003* − 0.138 0.529 − 0.633 < 0.001* 0.440 0.008* 0.163 0.457
  1. Gas:blood volume mismatch is the percent of lung mass accounted for by shunt, dead-space, and non-aerated, non-perfused regions. FiO2: fraction of inspired oxygen; PaO2: arterial oxygen partial pressure; PaCO2: arterial carbon dioxide partial pressure
  2. *Significant correlation, p < 0.05
  3. §Correlations computed only in intubated patients (N = 23)