Biomarker (n =) | With/without infection | Youden’s index on predicted probabilities | Biomarker’ cut-off values for Youden’s index | AUC [95%CI) (SE) | Sensitivity (95%CI) | Specificity (95%CI) | PPV (95%CI) | NPV (95%CI) | PLR (95%CI) | PLR (95%CI) |
---|---|---|---|---|---|---|---|---|---|---|
PSP [ng/ml] n = 631 | 369/262 | 0.49 | 44.18 | 0.81 [0.78, 0.85] (0.017) | 0.66 [0.61, 0.71] | 0.83 [0.78, 0.88] | 0.85 [0.81, 0.89] | 0.63 [0.58, 0.68] | 3.95 [2.99, 5.23] | 0.40 [0.35, 0.47] |
CRP [mg/ml] n = 629 | 369/260 | 0.39 | 99.05 | 0.77 [0.73, 0.80] (0.019) | 0.70 [0.66, 0.75] | 0.69 [0.63, 0.74] | 0.76 [0.72, 0.81] | 0.62 [0.56, 0.67] | 2.35 [1.92, 2.87] | 0.44 [0.38, 0.53] |
PCT [ng/ml] n = 527 | 175/352 | 0.44 | 0.20 | 0.78 [0.74, 0.82] (0.022) | 0.83 [0.79, 0.87] | 0.62 [0.54, 0.69] | 0.81 [0.78, 0.85] | 0.64 [0.56, 0.71] | 2.14 [1.77, 2.60] | 0.27 [0.21, 0.36] |